The anticarcinogen activity of β-arbutin on MCF-7 cells: Stimulation of apoptosis through estrogen receptor-α signal pathway, inflammation and genotoxicity

Ö Hazman, A Sarıova, MF Bozkurt… - Molecular and Cellular …, 2021 - Springer
Arbutin is one of the active ingredients employed in cosmetics as a skin whitening agent. In
the present study, the possible effects of arbutin on breast cancer were determined with …

[HTML][HTML] Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

A Ayuhastuti, ISK Syah, S Megantara, AY Chaerunisaa - Cosmetics, 2024 - mdpi.com
Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential
in cosmetic applications; however, its susceptibility to instability during storage poses a …

[HTML][HTML] The organogermanium compound THGP suppresses melanin synthesis via complex formation with L-DOPA on mushroom tyrosinase and in B16 4A5 …

J Azumi, T Takeda, Y Shimada, H Aso… - International journal of …, 2019 - mdpi.com
The organogermanium compound 3-(trihydroxygermyl) propanoic acid (THGP) has various
biological activities. We previously reported that THGP forms a complex with cis-diol …

Two faces of arbutin in hepatocellular carcinoma (HepG2) cells: Anticarcinogenic effect in high concentration and protective effect against cisplatin toxicity through its …

Ö Hazman, H Evin, MF Bozkurt, İH Ciğerci - Biologia, 2022 - Springer
Arbutin is one of the active substances frequently used as a skin whitening agent in cosmetic
products. Possible effects of arbutin on hepatocellular carcinoma (HepG2) cells and cisplatin …

Effects of the chloro-s-triazine herbicide terbuthylazine on DNA integrity in human and mouse cells

D Želježić, S Žunec, M Bjeliš, V Benković… - … science and pollution …, 2018 - Springer
Terbuthylazine belongs to the chloro-s-triazine group of herbicides and acts primarily as a
photosynthesis inhibitor. The mechanisms of action related to its exposure, relevant both in …

Discovery of anti-melanogenic components in persimmon (Diospyros kaki) leaf using LC-MS/MS-MN, AlphaFold2-enabled virtual screening and biological validation

J Liu, T Xu, J Ding, H Wen, J Meng, Q Liu, X Liu… - Food Chemistry, 2024 - Elsevier
Persimmon (Diospyros kaki) leaf is widely used as a tea substitute in East Asia, offering
potential health benefits. Although studies have highlighted their effects on …

Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells

AV Šobot, D Drakulić, A Todorović, M Janić… - Chemico-Biological …, 2024 - Elsevier
Abstract Gentiopicroside (Gp) and swertiamarin (Sm), secoiridoid glycosides commonly
found in plants of the Gentianaceae family, differ in one functional group. They exhibit …

Liver function and DNA integrity in hepatocytes of rats evaluated after treatments with strawberry tree (Arbutus unedo L.) water leaf extract and arbutin

K Jurica, V Benković, S Sikirić, N Kopjar… - Drug and chemical …, 2020 - Taylor & Francis
Due to their beneficial health effects, strawberry tree (Arbutus unedo L.) leaves have for
decades been used as herbal remedy in countries of the Mediterranean region. This pilot …

Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro

A Jurič, I Brčić Karačonji, S Žunec, A Katić… - Journal of apicultural …, 2022 - Taylor & Francis
Strawberry tree (Arbutus unedo L.) honey (STH) is widely used as part of traditional
medicine in the Mediterranean area, especially in the treatment of wounds, burns and …

Potential radioprotective properties of arbutin against ionising radiation on human leukocytes in vitro

V Benković, N Marčina, AH Knežević, D Šikić… - … /Genetic Toxicology and …, 2021 - Elsevier
Arbutin is a simple phenolic glucoside biosynthesised in many plant families. Some of the
everyday foods that contain arbutin are species of the genus Origanum, peaches, cereal …