Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

It has been reported that corticosteroid therapy was effective in the management of severe
acute respiratory syndrome (SARS) and the Middle East Respiratory Syndrome (MERS) …

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …

Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

Background Whether hydrocortisone, vitamin C, and thiamine treatment can reduce the
mortality of patients with sepsis is controversial. Research Question To evaluate the efficacy …

Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …

Objective To determine the effects of using unstructured clinical text in machine learning
(ML) for prediction, early detection, and identification of sepsis. Materials and methods …

Cytokines play a critical role in coordinating and amplifying a host immune response to
infection. The normal pattern of localized and systemic release of proinflammatory and anti …

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …