Virtual reality exergames for improving older adults' cognition and depression: a systematic review and meta-analysis of randomized control trials

HY Yen, HL Chiu - Journal of the American Medical Directors Association, 2021 - Elsevier
Objectives Virtual reality (VR) exergames are an innovative approach to promote older
adults' mental health. VR exergames are active video games controlled by bodily …

A perspective on multi-target drugs for Alzheimer's disease

O Benek, J Korabecny, O Soukup - Trends in pharmacological sciences, 2020 - cell.com
Alzheimer's disease (AD) has a complex pathophysiology that includes aggregation of
pathological proteins, impaired neurotransmission, increased oxidative stress, or microglia …

[HTML][HTML] Early-stage Alzheimer's disease prediction using machine learning models

C Kavitha, V Mani, SR Srividhya, OI Khalaf… - Frontiers in public …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the leading cause of dementia in older adults. There is currently
a lot of interest in applying machine learning to find out metabolic diseases like Alzheimer's …

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

NN Nalivaeva, AJ Turner - British journal of pharmacology, 2019 - Wiley Online Library
Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Modifiable risk factors for incident dementia and cognitive impairment: An umbrella review of evidence

YR Zhang, W Xu, W Zhang, HF Wang, YN Ou… - Journal of affective …, 2022 - Elsevier
Background Dementia and cognitive impairment can be attributed to genetic and modifiable
factors. Considerable evidence emerged in modifiable factors and urgently requires …

[HTML][HTML] Current pharmacotherapy and multi-target approaches for Alzheimer's disease

SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …

[HTML][HTML] Vascular dementia and underlying sex differences

F Akhter, A Persaud, Y Zaokari, Z Zhao… - Frontiers in aging …, 2021 - frontiersin.org
Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's
disease (AD); where Alzheimer's accounts for 60–70% of cases of dementia and VaD …

Age at diagnosis of atrial fibrillation and incident dementia

W Zhang, J Liang, C Li, D Gao, Q Ma, Y Pan… - JAMA Network …, 2023 - jamanetwork.com
Importance Epidemiological evidence regarding the association between atrial fibrillation
(AF) onset age and risk of incident dementia remains unexplored. Objective To examine …

[HTML][HTML] Neurovascular alterations in vascular dementia: emphasis on risk factors

S Lecordier, D Manrique-Castano… - Frontiers in aging …, 2021 - frontiersin.org
Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

[HTML][HTML] The roles of nitric oxide synthase/nitric oxide pathway in the pathology of vascular dementia and related therapeutic approaches

HY Zhu, FF Hong, SL Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …