Advancing tuberculosis management: the role of predictive, preventive, and personalized medicine

M Dohál, I Porvazník, I Solovič, J Mokrý - Frontiers in Microbiology, 2023 - frontiersin.org
Tuberculosis is a major global health issue, with approximately 10 million people falling ill
and 1.4 million dying yearly. One of the most significant challenges to public health is the …

Impact of Whole-Genome Sequencing of Mycobacterium tuberculosis on Treatment Outcomes for MDR-TB/XDR-TB: A Systematic Review

D Hazra, C Lam, K Chawla, V Sintchenko, VS Dhyani… - Pharmaceutics, 2023 - mdpi.com
The emergence and persistence of drug-resistant tuberculosis is a major threat to global
public health. Our objective was to assess the applicability of whole-genome sequencing …

Whole genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates collected in the Czech Republic, 2005–2020

M Dohál, V Dvořáková, M Šperková, M Pinková… - Scientific Reports, 2022 - nature.com
The emergence and spread of resistant tuberculosis (TB) pose a threat to public health, so it
is necessary to diagnose the drug-resistant forms in a clinically short time frame and closely …

Whole genome sequencing for tuberculosis in Victoria, Australia: a genomic implementation study from 2017 to 2020

K Dale, M Globan, K Horan, N Sherry… - The Lancet Regional …, 2022 - thelancet.com
Background Whole genome sequencing (WGS) is increasingly used by tuberculosis (TB)
programs to monitor Mycobacterium tuberculosis (Mtb) transmission. We aimed to …

Characterizing tuberculosis transmission dynamics in high-burden urban and rural settings

JP Smith, JE Oeltmann, AN Hill, JL Tobias, R Boyd… - Scientific reports, 2022 - nature.com
Mycobacterium tuberculosis transmission dynamics in high-burden settings are poorly
understood. Growing evidence suggests transmission may be characterized by extensive …

[HTML][HTML] Genomic transmission clusters and circulating lineages of Mycobacterium tuberculosis among refugees residing in refugee camps in Ethiopia

A Meaza, E Riviere, Z Bonsa, V Rennie… - Infection, Genetics and …, 2023 - Elsevier
Background Understanding the transmission dynamics of Mycobacterium tuberculosis (Mtb)
could benefit the design of tuberculosis (TB) prevention and control strategies for refugee …

Transmission of multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular epidemiological study

Q Duan, Z Zhang, D Tian, M Zhou, Y Hu, J Wu, T Wang… - Medicine, 2022 - journals.lww.com
Transmission of multidrug-resistant Mycobacterium tuberculos... : Medicine Transmission of
multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular …

[HTML][HTML] Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates in southeast Louisiana reveals persistent genetic clusters spanning multiple …

R Rose, A Feehan, BN Lain, D Ashcraft… - Journal of Infection and …, 2023 - Elsevier
Background We investigated 51 g-negative carbapenem-resistant Enterobacterales (CRE)
isolates collected from 22 patients over a five-year period from six health care institutions in …

Whole-Genome Sequencing Reveals Recent Transmission of Multidrug-Resistant Mycobacterium tuberculosis CAS1-Kili Strains in Lusaka, Zambia

JY Chizimu, ES Solo, P Bwalya, W Tanomsridachchai… - Antibiotics, 2021 - mdpi.com
Globally, tuberculosis (TB) is a major cause of death due to antimicrobial resistance.
Mycobacterium tuberculosis CAS1-Kili strains that belong to lineage 3 (Central Asian Strain …

An optimized genomic VCF workflow for precise identification of Mycobacterium tuberculosis cluster from cross-platform whole genome sequencing data

A Disratthakit, L Toyo-Oka, P Thawong… - Infection, Genetics and …, 2020 - Elsevier
Whole-genome sequencing (WGS) data allow for an inference of Mycobacterium
tuberculosis (Mtb) clusters by using a pairwise genetic distance of≤ 12 single nucleotide …