Abstract INTERFERON-γ (IFN-γ) is produced during the response to infection and
participates in immunostimulatory events. We have previously reported the induction of …

Clonal expansion of naive CD4 T cells is a necessary step in most adaptive immune
responses. Two distinct signals are required for clonal expansion to occur, ligation of T-cell …

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make
autoantibody by immunization of mice with the non-self protein human cytochrome c can …

Our goal has been to develop ways to tolerize the mature immune system to any defined
antigen. In this report we show that peripheral (post‐thymic) T cells of mice can become …

Generation of soluble T-cell receptor (TCR) molecules by a variety of genetic engineering
methods has been hampered by inefficient pairing of alpha and beta subunits in the …

Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in
addition to those transduced by the T cell antigen receptor. Recent work indicates that the T …

The mechanism by which tolerance is induced via systemic administration of high doses of
aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific …

The immune response of males and females is not identical but instead has been shown to
be dimorphic in its nature, with females generally demonstrating a greater overall response …

T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed
with mice expressing HEL on the thyroid epithelium, on pancreatic islet β cells, or …

The most efficient way to ensure self-tolerance in the T-cell repertoire is by intrathymic
deletion of self-reactive clones. Antigens not present intrathymically may, however, influence …