The mechanisms responsible for peripheral CD8 T cell tolerance to foreign Ags remain
poorly understood. In this study we have characterized the state of CD8 T cell tolerance …

Three models have been proposed to explain the inability of T lymphocytes to respond to
self-antigens (reviewed in 1):(a) self-reactive T cells are present but are prevented from …

The skin-associated immune system is the first line of defense against pathogenic attack
from the environment and is simultaneously tolerant to localized autoantigens and to …

Using TCR Vβ5 transgenic mice as a model system, we demonstrate that the induction of
peripheral tolerance can mold the TCR repertoire throughout adult life. In these mice, three …

Why T cells develop autoimmune reactivity to some antigens and tolerance to others is
unknown. Various mechanisms can provide for T-cell tolerance. These include deletion in …

It took nearly 100 years from the first description of mammary tumors in wild mice (Crisp,
1854) to the discovery that an extrachromosomal factor was responsible for the high …

It is generally accepted that there are two pathways of allorecognition, direct and indirect,
that together contribute to allograft rejection. Although it has been suggested that the direct …

The induction of donor-specific unresponsiveness constitutes the most desirable means of
securing long-term graft survival, as it would spare the recipient from the deleterious effects …

The induction of peripheral tolerance to alloantigen is accompanied in many cases by a
decrease in the production of cytokines such as IL-2 and IFN gamma, yet a sustained …

The fetus represents a foreign entity to the maternal immune system, yet this “natural”
allograft is not normally rejected. This unique situation provides a physiologic system to …