The technological landscape and applications of single-cell multi-omics
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …
simultaneously integrating various single-modality omics methods that profile the …
Mechanisms driving the immunoregulatory function of cancer cells
A van Weverwijk, KE de Visser - Nature Reviews Cancer, 2023 - nature.com
Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …
activation state of immune cells, which impacts their progression and response to …
Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI
C Liu, H Sun, Y Yi, W Shen, K Li, Y Xiao, F Li, Y Li… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …
progression leads to joint deformity and associated loss of function, which significantly …
Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites
The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chemical
models and laboratory experiments have predicted that these compounds can also be …
models and laboratory experiments have predicted that these compounds can also be …
[HTML][HTML] Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Antibiotic-resistant bacteria in aquaculture and climate change: A challenge for health in the Mediterranean area
Aquaculture is the productive activity that will play a crucial role in the challenges of the
millennium, such as the need for proteins that support humans and the respect for the …
millennium, such as the need for proteins that support humans and the respect for the …
Liquid biopsies: the future of cancer early detection
S Connal, JM Cameron, A Sala, PM Brennan… - Journal of translational …, 2023 - Springer
Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale
causing emotional, physical, and financial strains on individuals, families, and health care …
causing emotional, physical, and financial strains on individuals, families, and health care …
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease
JR Herdy, L Traxler, RK Agarwal, L Karbacher… - Cell Stem Cell, 2022 - cell.com
The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …
challenged by growing evidence of senescence-like features in terminally differentiated …