Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss
of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much …

Gene therapy has historically been defined as the addition of new genes to human cells.
However, the recent advent of genome-editing technologies has enabled a new paradigm in …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles.
Until now, numerous developments are made in SMTE; however, it is still challenging to …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

Duchenne muscular dystrophy (DMD) is a severe muscle-degenerative disease caused by a
mutation in the dystrophin gene. Genetic correction of patient-derived induced pluripotent …