[HTML][HTML] Modern risk stratification of acute myeloid leukemia in 2023: integrating established and emerging prognostic factors

E Boscaro, I Urbino, FM Catania, G Arrigo, C Secreto… - Cancers, 2023 - mdpi.com
Simple Summary Several factors, both patient-and disease-related, are essential to
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …

[HTML][HTML] AML classification in the year 2023: How to avoid a Babylonian confusion of languages

S Huber, C Baer, S Hutter, F Dicker, M Meggendorfer… - Leukemia, 2023 - nature.com
In parallel to the 5th edition of the World Health Organization Classification of
Haematolymphoid Tumours (WHO 2022), an alternative International Consensus …

Prognostic risk signature in patients with acute myeloid leukemia treated with hypomethylating agents and venetoclax

A Bataller, A Bazinet, CD DiNardo, A Maiti… - Blood …, 2024 - ashpublications.org
Hypomethylating agents (HMAs) and venetoclax (Ven) represent the standard of care for
patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy …

A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: The UK NCRI AML19 trial

J Othman, C Wilhelm-Benartzi, R Dillon… - Blood …, 2023 - ashpublications.org
Liposomal daunorubicin and cytarabine (CPX-351) improved overall survival (OS)
compared with 7+ 3 chemotherapy in older patients with secondary acute myeloid leukemia …

Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia

JGW McCarter, D Nemirovsky, CA Famulare… - Blood …, 2023 - ashpublications.org
Accurate classification and risk stratification are critical for clinical decision making in
patients with acute myeloid leukemia (AML). In the newly proposed World Health …

Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia

AA Lane, JS Garcia, EG Raulston, JL Garzon… - Blood …, 2024 - ashpublications.org
CD123, a subunit of the interleukin-3 receptor, is expressed on∼ 80% of acute myeloid
leukemias (AMLs). Tagraxofusp (TAG), recombinant interleukin-3 fused to a truncated …

Overcoming relapse: prophylactic or pre-emptive use of azacitidine or FLT3 inhibitors after allogeneic transplantation for AML or MDS

Y Najima - International Journal of Hematology, 2023 - Springer
Relapse remains the most critical obstacle in treatment by allogeneic hematopoietic stem
cell transplantation (HSCT). Non-relapse mortality has improved annually, but relapse …

Applicability of 2022 classifications of acute myeloid leukemia in the real-world setting

E Attardi, A Savi, B Borsellino, A Piciocchi… - Blood …, 2023 - ashpublications.org
The increasing knowledge of molecular genetics of acute myeloid leukemia (AML)
necessitated the update of previous diagnostic and prognostic schemes, which resulted in …

[HTML][HTML] Autologous stem cell transplantation in adult patients with intermediate-risk acute myeloid leukemia in first complete remission and no detectable minimal …

J Chen, M Labopin, T Pabst, X Zhang, E Jiang… - Bone marrow …, 2023 - nature.com
In patients with acute myeloid leukemia (AML) of intermediate-risk (IR) in first remission
(CR1) with no measurable residual disease (MRD negative), the choice of the best …

[HTML][HTML] TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Current Guidelines, Therapies, and Future Considerations

J DiGennaro, DA Sallman - Acta Haematologica, 2024 - karger.com
Background: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy
characterized by uncontrolled proliferation and impaired differentiation of myeloid cells in …