Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management

K Yerigeri, S Kadatane, K Mongan… - Journal of …, 2023 - Taylor & Francis
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy (TMA) defined by the
triad of hemolytic anemia, thrombocytopenia, and acute kidney injury. Microthrombi develop …

[HTML][HTML] Thrombotic microangiopathy after kidney transplantation: an underdiagnosed and potentially reversible entity

A Ávila, E Gavela, A Sancho - Frontiers in Medicine, 2021 - frontiersin.org
Thrombotic microangiopathy is a rare but serious complication that affects kidney transplant
recipients. It appears in 0.8–14% of transplanted patients and negatively affects graft and …

[HTML][HTML] Eculizumab rescue therapy in patients with recurrent atypical hemolytic uremic syndrome after kidney transplantation

C Duineveld, RN Bouwmeester, KL Wijnsma… - Kidney International …, 2023 - Elsevier
Introduction Since 2016, kidney transplantation in patients with atypical hemolytic uremic
syndrome (aHUS) in the Netherlands is performed without eculizumab prophylaxis …

[HTML][HTML] The role of genetic testing in the diagnostic workflow of pediatric patients with kidney diseases: the experience of a single institution

T Vaisitti, V Bracciamà, AC Faini, GM Brach Del Prever… - Human Genomics, 2023 - Springer
Purpose Inherited kidney diseases are among the leading causes of kidney failure in
children, resulting in increased mortality, high healthcare costs and need for organ …

New findings in preventing recurrence and improving renal function in AHUS patients after renal transplantation treated with eculizumab: a systemic review and meta …

ZC Tang, H Hui, C Shi, X Chen - Renal Failure, 2023 - Taylor & Francis
Background The long-term mortality of kidney transplantation patients with atypical
hemolytic uremic syndrome remains high, and the efficacy of the main treatment eculizumab …

[HTML][HTML] “Eculizumab First” in the Management of Posttransplant Thrombotic Microangiopathy

F Maritati, V Corradetti, C Bini, M Provenzano… - Kidney International …, 2024 - Elsevier
Introduction Posttransplant thrombotic microangiopathy (PT-TMA) is an uncommon event
that characterizes approximately 3% to 14% of kidney transplants (KTs), and that is …

[HTML][HTML] Atypical HUS triggered by COVID-19: a case report

V Tiwari, G Bhandari, A Gupta, P Gupta… - Indian Journal of …, 2022 - journals.lww.com
We hereby present a case of an atypical hemolytic uremic syndrome (aHUS) precipitated by
coronavirus disease 2019 (COVID-19). A 26-year-old male was diagnosed with COVID-19 …

Recurrent complement-mediated Hemolytic uremic syndrome after kidney transplantation

S Obata, F Hullekes, LV Riella, P Cravedi - Transplantation Reviews, 2024 - Elsevier
Hereditary forms of hemolytic uremic syndrome (HUS), formerly known as atypical HUS,
typically involve mutations in genes encoding for components of the alternative pathway of …

[HTML][HTML] Recommendations for the individualised management of atypical hemolytic uremic syndrome in adults

A Ávila, M Cao, M Espinosa, J Manrique… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Background Despite significant advances in therapeutic management of atypical hemolytic
uremic syndrome (aHUS), guidelines are not timely updated and achieving a consensus on …

[HTML][HTML] Unveiling the Incidence and Graft Survival Rate in Kidney Transplant Recipients With De Novo Thrombotic Microangiopathy: A Systematic Review and Meta …

CY Hsiung, HY Chen, SH Wang… - Transplant …, 2024 - frontierspartnerships.org
De novo thrombotic microangiopathy (TMA) is a rare and challenging condition in kidney
transplant recipients, with limited research on its incidence and impact on graft survival. This …