Stress induced microglial activation contributes to depression

B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Potential role of vitamin D for the management of depression and anxiety

GAS Casseb, MP Kaster, ALS Rodrigues - CNS drugs, 2019 - Springer
Vitamin D, a fat-soluble vitamin, plays a role not only in calcium and phosphate homeostasis
but also in several other functions, including cell growth and neuromuscular and immune …

Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression

X Xian, LL Cai, Y Li, RC Wang, YH Xu, YJ Chen… - Journal of …, 2022 - Springer
Background Neuroinflammation is an important component mechanism in the development
of depression. Exosomal transfer of MDD-associated microRNAs (miRNAs) from neurons to …

Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease

Y Lai, C Lin, X Lin, L Wu, Y Zhao, F Lin - Frontiers in aging …, 2022 - frontiersin.org
Introduction Alzheimer's disease is the most common dementia with clinical and
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …

Is depression the missing link between inflammatory mediators and cancer?

B Polityńska, O Pokorska, AM Wojtukiewicz… - Pharmacology & …, 2022 - Elsevier
Patients with cancer are at greater risk of developing depression in comparison to the
general population and this is associated with serious adverse effects, such as poorer …

Translational evidence for the Inflammatory Response System (IRS)/Compensatory Immune Response System (CIRS) and neuroprogression theory of major …

M Debnath, M Berk, M Maes - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Major depressive disorder (MDD) is a common, severe and disabling neuropsychiatric
disorder with a heterogenous etiology. Among the most widely recognized etiological …

Microglia pyroptosis: a candidate target for neurological diseases treatment

X Wu, T Wan, X Gao, M Fu, Y Duan, X Shen… - Frontiers in …, 2022 - frontiersin.org
In addition to its profound implications in the fight against cancer, pyroptosis have important
role in the regulation of neuronal injury. Microglia are not only central members of the …

Inflammation-associated synaptic alterations as shared threads in depression and multiple sclerosis

A Bruno, E Dolcetti, FR Rizzo, D Fresegna… - Frontiers in Cellular …, 2020 - frontiersin.org
In the past years, several theories have been advanced to explain the pathogenesis of Major
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …

Inflammation as the common biological link between depression and cardiovascular diseases: can carnosine exert a protective role?

G Caruso, CG Fresta, M Grasso… - Current Medicinal …, 2020 - ingentaconnect.com
Several epidemiological studies have clearly shown the high co-morbidity between
depression and Cardiovascular Diseases (CVD). Different studies have been conducted to …

Aerobic exercise inhibits CUMS-depressed mice hippocampal inflammatory response via activating hippocampal miR-223/TLR4/MyD88-NF-κB pathway

H Qu, R Liu, J Chen, L Zheng, R Chen - International Journal of …, 2020 - mdpi.com
Objective: To investigate the role of aerobic exercise in inhibiting chronic unpredictable mild
stress (CUMS) depressed mice hippocampal inflammatory response and its potential …