Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long
consequences. While there is still no effective therapy available, the results of past research …

For over a century, axon regeneration has been considered the Holy Grail for spinal cord
injury (SCI) repair. Although there are other factors that could contribute to improving …

Previous studies demonstrated that neural progenitor cells (NPCs) transplanted into a
subacute contusion injury improve motor, sensory, and bladder function. In this study we …

Following spinal cord injury (SCI), pathological reflexes develop that result in altered
bladder function and sphincter dis-coordination, with accompanying changes in the …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Study design: This is a Delphi study. Objectives: Defining variables that potentially influence
the outcomes of an animal study regarding pathophysiology of traumatic spinal cord injury …

Mitochondrial homeostasis is essential for maintaining cellular function and survival in the
central nervous system (CNS). Mitochondrial function is significantly compromised after …

Toll-like receptors (TLRs) are mediators of the innate immune response to exogenous
pathogens. They have also been implicated in sterile inflammation associated with systemic …

This study was undertaken as part of the NIH “Facilities of Research Excellence-Spinal Cord
Injury” project to support independent replication of published studies. Here, we repeat key …

The purpose of this study is to develop a rat lumbosacral spinal cord injury (SCI) model that
causes consistent motoneuronal loss and behavior deficits. Most SCI models focus on the …