Acute and chronic inflammatory diseases of the intestine impart a significant and negative
impact on the health and well-being of human and non-human mammalian animals …

Site specific bioavailability and metabolism of levosimendan was studied in ten dogs by
placing intestinal access port catheters in different parts of the gastrointestinal tract. 14C …

It was previously demonstrated that a biologically active insulin could cross the mucosal
membrane in the gut by using surface active substances. In this report we describe studies …

Ileal fluxes, urinary losses and taurine balance were determined in six taurine-replete and
four taurine-depleted cats. Digesta samples collected at the terminal ileum were used to …

The present study uses the cannulated dog to verify the major elements of gastrointestinal
(GI) motility affecting the performance of oral sustained release dosage forms. It appears that …

Designing orally administered colonic delivery systems is complicated because the colon,
located at the end of the alimentary canal, is difficult to access. Nevertheless, if drugs could …

Hydrogels for oral controlled drug delivery must swell as they move through the various
regions of the gastrointestinal tract. Residence time in these different regions, coupled with …

The choice of techniques used to study gastrointestinal motility depends upon the question
(s) being addressed. Oftentimes the question involves the motility response as it relates to …

The gastrointestinal tract from the stomach to the anus contains the same basic structure. On
the luminal surface there is a single layer of columnar epithelial cells with specialized cells …