A review of innate and adaptive immunity to coccidioidomycosis

CY Hung, AP Hsu, SM Holland, J Fierer - Medical mycology, 2019 - academic.oup.com
Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores
produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common …

[HTML][HTML] The Rise of Coccidioides: Forces Against the Dust Devil Unleashed

MCC Van Dyke, GR Thompson 3rd… - Frontiers in …, 2019 - frontiersin.org
Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of
Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of …

Glucan-chitin particles enhance Th17 response and improve protective efficacy of a multivalent antigen (rCpa1) against pulmonary Coccidioides posadasii infection

CY Hung, H Zhang, N Castro-Lopez… - Infection and …, 2018 - Am Soc Microbiol
Developing an effective and safe recombinant vaccine requires microbe-specific antigens
combined with an adjuvant/delivery system to strengthen protective immunity. In this study …

Construction and evaluation of a novel recombinant T cell epitope-based vaccine against coccidioidomycosis

BJ Hurtgen, CY Hung, GR Ostroff, SM Levitz… - Infection and …, 2012 - Am Soc Microbiol
Clinical and animal studies of coccidioidomycosis have demonstrated that activated CD4+ T
lymphocytes are essential for protection against this fungal respiratory disease. We …

Investigating the relationship between climate and valley fever (coccidioidomycosis)

EA Weaver, KN Kolivras - EcoHealth, 2018 - Springer
Valley fever (coccidioidomycosis) is a disease caused by inhalation of spores from the soil-
dwelling Coccidioides fungal species. The disease is endemic to semiarid areas in the …

[HTML][HTML] Immune response to coccidioidomycosis and the development of a vaccine

N Castro-Lopez, CY Hung - Microorganisms, 2017 - mdpi.com
Coccidioidomycosis is a fungal infection caused by Coccidioides posadasii and
Coccidioides immitis. It is estimated that 150,000 new infections occur in the United States …

Vaccine immunity against fungal infections

SG Nanjappa, BS Klein - Current opinion in immunology, 2014 - Elsevier
Vaccines have been hailed as one of the greatest achievements in the public health during
the past century. The global eradication of Smallpox virus in humans and Rinderpest virus in …

Extracellular ammonia at sites of pulmonary infection with Coccidioides posadasii contributes to severity of the respiratory disease

HZ Wise, CY Hung, E Whiston, JW Taylor… - Microbial pathogenesis, 2013 - Elsevier
Coccidioides is the causative agent of a potentially life-threatening respiratory disease of
humans. A feature of this mycosis is that pH measurements of the microenvironment of …

CARD9-associated Dectin-1 and Dectin-2 are required for protective immunity of a multivalent vaccine against Coccidioides posadasii infection

A Campuzano, H Zhang, GR Ostroff… - The Journal of …, 2020 - journals.aai.org
Coccidioides species are fungal pathogens that can cause a widely varied clinical
manifestation from mild pulmonary symptom to disseminated, life-threatening disease. We …

Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection

CY Hung, MP Jiménez-Alzate, A Gonzalez… - Infection and …, 2014 - Am Soc Microbiol
ABSTRACT Interleukin-17A (IL-17A)-producing CD4+ T helper (Th17) cells have been
shown to be essential for defense against pulmonary infection with Coccidioides species …