Osteosarcoma: A comprehensive review of management and treatment strategies

F Jafari, S Javdansirat, S Sanaie, A Naseri… - Annals of diagnostic …, 2020 - Elsevier
Osteosarcoma, a bone cancer usually seen in children and young adults, is generally a high-
grade malignancy presented by extreme metastases to the lungs. Osteosarcoma has a …

[HTML][HTML] Bone cancer: diagnosis and treatment principles

JL Ferguson, SP Turner - American family physician, 2018 - aafp.org
Primary bone cancers include osteosarcoma, Ewing sarcoma, and chondrosarcoma. They
account for less than 1% of diagnosed cancers each year and are associated with significant …

[HTML][HTML] Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

S Simpson, MD Dunning, S de Brot… - Acta Veterinaria …, 2017 - Springer
Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are
27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA …

D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy

C Du, M Zhou, F Jia, L Ruan, H Lu, J Zhang, B Zhu… - Biomaterials, 2021 - Elsevier
Osteosarcoma is a common type of bone cancers with a high rate of pulmonary recurrence.
High-dose radiation therapy is useful for the ablation of unresectable osteosarcoma …

[HTML][HTML] Suppressing STAT5 signaling affects osteosarcoma growth and stemness

D Subramaniam, P Angulo, S Ponnurangam… - Cell death & …, 2020 - nature.com
Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children
and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the …

[HTML][HTML] miR-143-3p inhibits the proliferation, migration and invasion in osteosarcoma by targeting FOSL2

X Sun, G Dai, L Yu, Q Hu, J Chen, W Guo - Scientific reports, 2018 - nature.com
Osteosarcoma (OS) is the most common type of primary malignant bone tumor and mainly
occurs in children and adolescent. Because of its early migration and invasion, OS has a …

[HTML][HTML] International society of paediatric surgical oncology (IPSO) surgical practice guidelines

SCV Abib, CH Chui, S Cox, AH Abdelhafeez… - …, 2022 - ncbi.nlm.nih.gov
Most children with tumors will require one or more surgical interventions as part of the care
and treatment, including making a diagnosis, obtaining adequate venous access …

Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway

Z Ma, J Yang, Y Yang, X Wang, G Chen, A Shi, Y Lu… - Phytomedicine, 2020 - Elsevier
Background Osteosarcoma is the most common type of primary malignant bone tumor. This
disease has exhibited a progressively lower survival rate over the past several decades …

Glaucocalyxin A reverses EMT and TGF-β1-induced EMT by inhibiting TGF-β1/Smad2/3 signaling pathway in osteosarcoma

X Jiang, Z Zhang, C Song, H Deng, R Yang… - Chemico-biological …, 2019 - Elsevier
Metastatic osteosarcoma usually has an unsatisfactory response to the current standard
chemotherapy and causes poor prognosis. Currently, epithelial-mesenchymal transition …

[HTML][HTML] Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma

L Wang, X Huang, X You, T Yi, B Lu, J Liu… - Signal transduction and …, 2020 - nature.com
The adaptation of osteosarcoma cells to therapeutic pressure impedes the efficacy of
chemotherapy for osteosarcoma. However, the characteristics and cellular organization of …