Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase

P Masson, Z Shaihutdinova, O Lockridge - Biochemical Pharmacology, 2023 - Elsevier
Butyrylcholinesterase (BChE) is present in plasma and numerous cells and organs. Its
physiological function (s) is (are) still unclear. However, this enzyme is of pharmacological …

Coronavirus disease pathophysiology: biomarkers, potential new remedies, comorbidities, long COVID-19, post pandemic epidemiological surveillance

JZ Kubiak, M Kloc - International Journal of Molecular Sciences, 2023 - mdpi.com
IJMS | Free Full-Text | Coronavirus Disease Pathophysiology: Biomarkers, Potential New
Remedies, Comorbidities, Long COVID-19, Post Pandemic Epidemiological Surveillance Next …

A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy

N Sakander, A Ahmed, M Bhardwaj, D Kumari… - Bioorganic …, 2024 - Elsevier
Coronaviruses are a group of enveloped viruses with non-segmented, single-stranded, and
positive-sense RNA genomes. It belongs to the 'Coronaviridae family', responsible for …

Effects of Surface Morphology and Type of Cross-Linking of Chitosan-Pectin Microspheres on Their Degree of Swelling and Favipiravir Release Behavior

AR Hameed, H Majdoub, FH Jabrail - Polymers, 2023 - mdpi.com
The cross-linked microspheres were prepared and loaded with Favipiravir SARS-CoV-2
antiviral drug, by copolymerization of chitosan (CS) with a polysaccharide extracted from …

Quality assessment and characterization of unregulated antiviral drugs for feline infectious peritonitis: implications for treatment, safety, and efficacy

AJ Mulligan, ME Browning - American Journal of Veterinary …, 2024 - Am Vet Med Assoc
OBJECTIVE Feline infectious peritonitis is fatal, and due to lack of approved treatments,
unregulated antiviral drugs are used to treat this disease. This study set out to determine the …

[HTML][HTML] Binding mechanism of pentamidine derivatives with human serum acute phase protein α1-acid glycoprotein

T Żołek, O Dömötör, J Żabiński - International Journal of Biological …, 2024 - Elsevier
Drug binding and interactions with plasma proteins play a crucial role in determining the
efficacy of drug delivery, thus significantly impacting the overall pharmacological effect. AGP …

A novel ZrO2@ PVA-PPy nanocomposite based electrochemical sensor for detection of anti Covid-19 drug Favipiravir in formulation, human plasma and various …

HS El-Desoky, E Mashaly, M Gaber, EA Bakr - Microchemical Journal, 2024 - Elsevier
A novel ZrO 2 doped polymeric nanocomposite based on ZrO 2 nanorods and conducting
polymers of polyvinyl alcohol and polypyrrole (ZrO 2@ PVA-PPy) was synthesized and …

[HTML][HTML] In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692

O Dömötör, M Mathuber, CR Kowol - European Journal of Pharmaceutical …, 2024 - Elsevier
Binding towards human serum albumin (HSA) and α1-acid glycoprotein (AGP) of three
approved fibroblast growth factor receptor (FGFR) inhibitors ponatinib (PON), nintedanib …

Electrochemical Investigations and Molecular Docking Analysis to Evaluate the Molnupiravir-Calf Thymus dsDNA Interaction

I Kucuk, DN Unal, A Karayel… - Journal of The …, 2024 - iopscience.iop.org
Molnupiravir (MLP) is an important antiviral drug recommended for the treatment of COVID-
19. In order to design new pharmaceuticals, exploring drug and DNA interaction is crucial …

Eco‐Friendly Analytical Approaches for the Quantification of Molnupiravir and Favipiravir Using Capillary Zone Electrophoresis and Derivative Ratio …

MS Nasr, W Talaat, MMY Kaddah, G Omran… - …, 2024 - Wiley Online Library
Designing new validated analytical procedures with a focus on many objectives, such as
simplicity, environmental friendliness, analytical effectiveness, and sustainability, has grown …