Ca2+ as a therapeutic target in cancer
S Gross, P Mallu, H Joshi, B Schultz, C Go… - Advances in cancer …, 2020 - Elsevier
Ca 2+ is a ubiquitous and dynamic second messenger molecule that is induced by many
factors including receptor activation, environmental factors, and voltage, leading to …
factors including receptor activation, environmental factors, and voltage, leading to …
[HTML][HTML] Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
MH Ashoub, R Razavi, K Heydaryan… - European Journal of …, 2024 - Springer
The latest findings in iron metabolism and the newly uncovered process of ferroptosis have
paved the way for new potential strategies in anti-leukemia treatments. In the current project …
paved the way for new potential strategies in anti-leukemia treatments. In the current project …
Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor
Abstract mTOR, as a serine/threonine kinase, is a widely pursued anticancer target. Multiple
clinical trials of mTOR kinase inhibitors are ongoing, but their specificity and safety features …
clinical trials of mTOR kinase inhibitors are ongoing, but their specificity and safety features …
Developing therapeutic approaches for chronic myeloid leukemia: a review
Modern clinical therapy of chronic myeloid leukemia (CML) with TKIs is highly efficacious in
most CML patients, while it is not remedial and generally confined due to intolerance or …
most CML patients, while it is not remedial and generally confined due to intolerance or …
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia
Patients with chronic myeloid leukemia (CML) who are treated with tyrosine kinase inhibitors
(TKIs) experience significant heterogeneity regarding depth and speed of responses …
(TKIs) experience significant heterogeneity regarding depth and speed of responses …
Suppression of Ca2+ signaling enhances melanoma progression
The role of store‐operated Ca2+ entry (SOCE) in melanoma metastasis is highly
controversial. To address this, we here examined UV‐dependent metastasis, revealing a …
controversial. To address this, we here examined UV‐dependent metastasis, revealing a …
[HTML][HTML] Targeting abnormal hematopoietic stem cells in chronic myeloid leukemia and philadelphia chromosome-negative classical myeloproliferative neoplasms
Y Yung, E Lee, HT Chu, PK Yip, H Gill - International journal of molecular …, 2021 - mdpi.com
Myeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing
mutations that constitutively activate the signal-transduction pathways involved in …
mutations that constitutively activate the signal-transduction pathways involved in …
[HTML][HTML] Crosstalk between CML cells with HUVECs and BMSCs through exosomes
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by
presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL …
presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL …
Combined therapy of ATRA and imatinib mesylate decreases BCR-ABL and ABCB1/MDR1 expression through cellular differentiation in a chronic myeloid leukemia …
CA Pinto, AJS Portilho, MC Barbosa, MEA De Moraes… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative disease,
and a major challenge for the eradication of CML is to understand the cause of the …
and a major challenge for the eradication of CML is to understand the cause of the …
[HTML][HTML] USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
P van den Berk, C Lancini, M Serresi… - Cell Reports, 2020 - cell.com
Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects
hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB …
hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB …