Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells
C Grandjenette, M Schnekenburger, A Gaigneaux… - Cancer Letters, 2020 - Elsevier
Although tyrosine kinase inhibitors (TKIs) revolutionized the management of chronic myeloid
leukemia (CML), resistance against TKIs and leukemia stem cell (LSC) persistence remain a …
leukemia (CML), resistance against TKIs and leukemia stem cell (LSC) persistence remain a …
[HTML][HTML] NK3. 3-Derived Extracellular Vesicles Penetrate and Selectively Kill Treatment-Resistant Tumor Cells
A McCune, J Kornbluth - Cancers, 2023 - mdpi.com
Simple Summary Many cancer treatments become ineffective as tumor cells develop
resistance and escape, resulting in patient relapse and tumor spread. Therefore, there is an …
resistance and escape, resulting in patient relapse and tumor spread. Therefore, there is an …
Identification of key candidate targets and pathways for the targeted treatment of leukemia stem cells of chronic myelogenous leukemia using bioinformatics analysis
H Li, L Liu, J Zhuang, C Liu, C Zhou… - … Genetics & Genomic …, 2019 - Wiley Online Library
Background Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that
arises from the acquisition of constitutively active BCR‐ABL tyrosine kinase in hematopoietic …
arises from the acquisition of constitutively active BCR‐ABL tyrosine kinase in hematopoietic …
[HTML][HTML] Effects of neuropeptide substance P on proliferation and β-cell differentiation of adult pancreatic ductal cells
N Zhang, D Gao, Y Liu, S Ji, L Sha - Frontiers in Neuroscience, 2018 - frontiersin.org
Purpose: The pancreas is innervated by sensory nerves, parasympathetic and sympathetic
nerves. The classical neurotransmitters, acetylcholine and noradrenaline, and some kind of …
nerves. The classical neurotransmitters, acetylcholine and noradrenaline, and some kind of …
[HTML][HTML] PI3-kinase inhibition as a strategy to suppress the leukemic stem cell niche in Ph+ chronic myeloid leukemia
Y Filik, K Bauer, E Hadzijusufovic, P Haider… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Recent data suggest that the disease-associated microenvironment, known as the leukemic
stem cell (LSC) niche, is substantially involved in drug resistance of LSC in BCR-ABL1+ …
stem cell (LSC) niche, is substantially involved in drug resistance of LSC in BCR-ABL1+ …
From bench to bedside: bridging the gaps in best practices for real-world chronic myeloid leukemia care
GM Assanto, E Scalzulli, I Carmosino… - Expert Review of …, 2022 - Taylor & Francis
Introduction Although tyrosine kinase inhibitors (TKIs) determined an improvement of
responses and overall survival (OS) in chronic phase chronic myeloid leukemia (CP-CML) …
responses and overall survival (OS) in chronic phase chronic myeloid leukemia (CP-CML) …
Impedimetric gene assay for BCR/ABL transcripts in plasmids of patients with chronic myeloid leukemia
KYP dos Santos Avelino, IAM Frías, N Lucena-Silva… - Microchimica Acta, 2018 - Springer
A label-free impedimetric biosensor was developed for determination of BCR/ABL
transcripts. Specific DNA primers were covalently immobilized on a gold electrode modified …
transcripts. Specific DNA primers were covalently immobilized on a gold electrode modified …
[HTML][HTML] In vitro and ex vivo anti‑tumor effect and mechanism of Tucatinib in leukemia stem cells and ABCG2‑overexpressing leukemia cells
W Jing, M Zhou, R Chen, X Ye, W Li… - Oncology …, 2021 - spandidos-publications.com
Leukemia stem cells (LSCs), which evade standard chemotherapy, may lead to
chemoresistance and disease relapse. The overexpression of ATP‑binding cassette …
chemoresistance and disease relapse. The overexpression of ATP‑binding cassette …
[HTML][HTML] Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
SY Jeong, J Lyu, JA Kim, IH Oh - Experimental & Molecular Medicine, 2020 - nature.com
The importance of modulating the intensity of Wnt signaling has been highlighted in various
biological models, but their mechanisms remain unclear. In this study, we found that Ryk …
biological models, but their mechanisms remain unclear. In this study, we found that Ryk …
[HTML][HTML] Current Progress on the Influence Human Genetics Has on the Efficacy of Tyrosine Kinase Inhibitors Used to Treat Chronic Myeloid Leukemia
TC Prakash, S Enkemann - Cureus, 2024 - ncbi.nlm.nih.gov
The use of tyrosine kinase inhibitors (TKIs) has become the mainstay of treatment in patients
suffering from chronic myeloid leukemia (CML), an adult leukemia caused by a reciprocal …
suffering from chronic myeloid leukemia (CML), an adult leukemia caused by a reciprocal …