Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
The functional importance of gene enhancers in regulated gene expression is well
established,,. In addition to widespread transcription of long non-coding RNAs (lncRNAs) in …
established,,. In addition to widespread transcription of long non-coding RNAs (lncRNAs) in …
GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast
AL Scaling, ER Prossnitz, HJ Hathaway - Hormones and Cancer, 2014 - Springer
Abstract 17β-Estradiol (estrogen), through receptor binding and activation, is required for
mammary gland development. Estrogen stimulates epithelial proliferation in the mammary …
mammary gland development. Estrogen stimulates epithelial proliferation in the mammary …
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
SN Vasilatos, TA Katz, S Oesterreich, Y Wan… - …, 2013 - academic.oup.com
Our previous studies demonstrated that lysine-specific demethylase 1 (LSD1) and histone
deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However …
deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However …
Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2
Y Zhang, G Eades, Y Yao, Q Li, Q Zhou - Journal of Biological Chemistry, 2012 - ASBMB
Several reports have indicated that miR-140, a possible tumor suppressor microRNA (miR),
is down-regulated in breast tumors compared with normal breast tissues. However, the role …
is down-regulated in breast tumors compared with normal breast tissues. However, the role …
[HTML][HTML] Androgen receptor as a targeted therapy for breast cancer
JP Garay, BH Park - American journal of cancer research, 2012 - ncbi.nlm.nih.gov
Breast cancer occurs at a high frequency in women and, given this fact, a primary focus of
breast cancer research has been the study of estrogen receptor α (ER) signaling. However …
breast cancer research has been the study of estrogen receptor α (ER) signaling. However …
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers
M Mohseni, J Cidado, S Croessmann… - Proceedings of the …, 2014 - National Acad Sciences
Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers.
However, few molecular mediators of tamoxifen resistance have been elucidated. Here we …
However, few molecular mediators of tamoxifen resistance have been elucidated. Here we …
PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells
EM Al-Hujaily, AG Mohamed, I Al-Sharif… - Breast Cancer Research …, 2011 - Springer
We have investigated here the anti-breast cancer properties of two novel curcumin
analogues, EAC and PAC. Apoptosis was assessed by the annexin V/propidium iodide (PI) …
analogues, EAC and PAC. Apoptosis was assessed by the annexin V/propidium iodide (PI) …
Estrogen receptor α mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death
Estrogen receptors (ER) are expressed in∼ 65% of human breast cancer. Cumulative data
from clinical trials and retrospective analyses suggest that some chemotherapeutic agents …
from clinical trials and retrospective analyses suggest that some chemotherapeutic agents …
Hypoxia alters the response to anti-EGFR therapy by regulating EGFR expression and downstream signaling in a DNA methylation–specific and HIF-dependent …
M Mamo, IC Ye, JW DiGiacomo, JY Park, B Downs… - Cancer research, 2020 - AACR
Intratumoral hypoxia occurs in 90% of solid tumors and is associated with a poor prognosis
for patients. Cancer cells respond to hypoxic microenvironments by activating the …
for patients. Cancer cells respond to hypoxic microenvironments by activating the …
The growth response to androgen receptor signaling in ER α-negative human breast cells is dependent on p21 and mediated by MAPK activation
JP Garay, B Karakas, AM Abukhdeir… - Breast Cancer …, 2012 - Springer
Introduction Although a high frequency of androgen receptor (AR) expression in human
breast cancers has been described, exploiting this knowledge for therapy has been …
breast cancers has been described, exploiting this knowledge for therapy has been …