Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this
conference was to develop an expert consensus-driven working framework for …

This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer
(PCa) risk but a wide range of risk estimates have been reported that are based on …

Purpose: Increased prostate cancer risk has been reported for BRCA mutation carriers, but
BRCA-associated clinicopathologic features have not been clearly defined. Experimental …

Objective Evidence shows that gene mutation is a significant proportion of genetic factors
associated with prostate cancer. The DNA damage response (DDR) is a signal cascade …

Beyond breast and ovarian cancers, mutations in the BRCA1 and BRCA2 genes increase
risks for pancreatic and prostate cancers and contribute to the prevalence of these cancers …

Prostate cancer has a strong familial component but uncovering the molecular basis for
inherited susceptibility for this disease has been challenging. Recently, a rare, recurrent …

One of the strongest risk factors for prostate cancer is a family history of the disease.
Germline mutations in the breast cancer predisposition gene 2 (BRCA2) are the genetic …

Several ongoing international prostate cancer (PC) clinical trials are exploring therapies that
target the DNA damage response (DDR) pathway. This systematic review summarizes the …

Background: Prostate cancer (PrCa) is one of the most common diseases to affect men
worldwide and among the leading causes of cancer-related death. The purpose of this study …