Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …

Aging is linked to the deterioration of many physical and cognitive abilities and is the leading
risk factor for Alzheimer's disease. The growing aging population is a significant healthcare …

A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and-
benzothiazole Ir (III) dppz complexes [Ir (C^ N) 2 (dppz)]+, Ir1–Ir4, were rationally designed …

Glycogen storage disease XI, also known as Fanconi-Bickel syndrome (FBS), is a rare
autosomal recessive disorder caused by mutations in the SLC2A2 gene that encodes the …

The multisubunit HOPS tethering complex is a well-established regulator of lysosome fusion
with late endosomes and autophagosomes. However, the role of the HOPS complex in other …

Autophagy is important for cellular homeostasis and to prevent the abnormal accumulation
of proteins. While many proteins that comprise the canonical autophagy pathway have been …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Cells release extracellular vesicles (EVs) of different sizes. Small EVs (< 200 nm) can
originate from the fusion of multivesicular bodies with the plasma membrane, ie exosomes …

The acrosome is a lysosome‐related vesicular organelle located in the sperm head. The
acrosomal reaction (AR) is an exocytic process mediated by Ca2+ and essential for …