[HTML][HTML] Current sepsis therapeutics

JL Vincent - EBioMedicine, 2022 - thelancet.com
Management of the patient with sepsis comprises three key branches: control of the
underlying infection, haemodynamic stabilization, and modulation of the host response …

Current practice and evolving concepts in septic shock resuscitation

J Bakker, E Kattan, D Annane, R Castro… - Intensive care …, 2022 - Springer
Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …

Timing of vasopressin initiation and mortality in patients with septic shock: analysis of the MIMIC-III and MIMIC-IV databases

J Xu, H Cai, X Zheng - BMC Infectious Diseases, 2023 - Springer
Background vasopressin is commonly used as a second-line vasopressor for patients with
septic shock, but the optimal timing of initiation is uncertain. This study was designed to …

Non-hemodynamic effects of catecholamines

C Hartmann, P Radermacher, M Wepler, B Nußbaum - Shock, 2017 - journals.lww.com
Circulatory shock is defined as an imbalance between tissue oxygen supply and demand,
and mostly results from a loss of blood volume, cardiac pump failure, and/or reduction of …

Sepsis and infection: Two words that should not be confused

JL Vincent - Frontiers in Medicine, 2023 - frontiersin.org
The underlying cause of sepsis is a dysregulated host response to infection, leading to
multiple organ failure. Identifying sepsis is crucial because of the associated …

Effect of vasopressors on the macro-and microcirculation during systemic inflammation in humans in vivo

LM Van Loon, RF Stolk, JG Van Der Hoeven… - Shock, 2020 - journals.lww.com
Aim: Comparing the effects of different vasopressors in septic shock patients is hampered by
high heterogeneity and the fact that current guidelines dictate the use of norepinephrine …

Norepinephrine vs vasopressin: which vasopressor should be discontinued first in septic shock? A meta-analysis

Z Wu, S Zhang, J Xu, J Xie, L Huang, Y Huang, Y Yang… - Shock, 2020 - journals.lww.com
Background: Patients with septic shock in whom norepinephrine (NE) infusion alone is
insufficient to raise blood pressure require the concomitant administration of vasopressin …

The efficacy and safety of esmolol for septic shock: a systematic review and meta-analysis of randomized controlled trials

P Huang, X Zheng, Z Liu, X Fang - Frontiers in pharmacology, 2021 - frontiersin.org
Purpose: The meta-analysis aims to identify whether septic shock patients can benefit from
esmolol. Materials and Methods: The relevant studies from MEDLINE, Cochrane Library …

Renal autoregulation in experimental septic shock and its response to vasopressin and norepinephrine administration

EH Post, F Su, C Righy Shinotsuka… - Journal of Applied …, 2018 - journals.physiology.org
Evidence suggests that septic shock patients with chronic arterial hypertension may benefit
from resuscitation targeted to achieve higher blood pressure values than other patients …

Renal autoregulation in experimental septic shock and its response to vasopressin and norepinephrine administration 2

JL Vincent - journals.physiology.org
Evidence suggests that septic shock patients with chronic arterial hypertension may 34
benefit from resuscitation targeted to achieve higher blood pressure values than other 35 …