Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment

X Song, W Wei, W Cheng, H Zhu, W Wang… - Frontiers in Cellular …, 2022 - frontiersin.org
Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …

Infectious disease-associated encephalopathies

MC Barbosa-Silva, MN Lima, D Battaglini, C Robba… - Critical Care, 2021 - Springer
Infectious diseases may affect brain function and cause encephalopathy even when the
pathogen does not directly infect the central nervous system, known as infectious disease …

Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies

ML Chou, AO Babamale, TL Walker, F Cognasse… - Trends in …, 2023 - cell.com
Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …

Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

OB Akide Ndunge, N Kilian, MM Salman - Advanced Science, 2022 - Wiley Online Library
Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …

Dissecting the mechanisms of pathogenesis in cerebral malaria

A Ramachandran, A Sharma - PLoS pathogens, 2022 - journals.plos.org
Cerebral malaria (CM) is one of the leading causes of death due to malaria. It is
characterised by coma, presence of asexual parasites in blood smear, and absence of any …

Microglial priming in infections and its risk to neurodegenerative diseases

MN Lima, MC Barbosa-Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Infectious diseases of different etiologies have been associated with acute and long-term
neurological consequences. The primary cause of these consequences appears to be an …

Malaria related neurocognitive deficits and behavioral alterations

P Rosa-Gonçalves, FL Ribeiro-Gomes… - Frontiers in Cellular …, 2022 - frontiersin.org
Typical of tropical and subtropical regions, malaria is caused by protozoa of the genus
Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a …

Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture

B Othman, L Zeef, T Szestak, Z Rchiad, J Storm… - Plos one, 2023 - journals.plos.org
The human malaria parasite Plasmodium falciparum is responsible for the majority of
mortality and morbidity caused by malaria infection and differs from other human malaria …

Parasite infections, neuroinflammation, and potential contributions of gut microbiota

J Alloo, I Leleu, C Grangette, S Pied - Frontiers in Immunology, 2022 - frontiersin.org
Many parasitic diseases (including cerebral malaria, human African trypanosomiasis,
cerebral toxoplasmosis, neurocysticercosis and neuroschistosomiasis) feature acute or …

Association between altered cognition and Loa loa microfilaremia: First evidence from a cross-sectional study in a rural area of the Republic of Congo

T Checkouri, F Missamou, SDS Pion… - PLOS Neglected …, 2023 - journals.plos.org
Background Individuals with high Loa loa microfilarial densities are at risk of developing
severe encephalopathy after administration of antiparasitic drugs. Apart from this finding …