Role of ROS and RNS sources in physiological and pathological conditions
S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …
and nitrogen species play a double role, because they can cause oxidative damage and …
Lysosomal cell death at a glance
S Aits, M Jäättelä - Journal of cell science, 2013 - journals.biologists.com
Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …
Lysosomal membrane permeabilization in cell death
Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …
Hepatocyte death: a clear and present danger
H Malhi, ME Guicciardi, GJ Gores - Physiological reviews, 2010 - journals.physiology.org
The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …
Nanomaterial cytotoxicity is composition, size, and cell type dependent
SK Sohaebuddin, PT Thevenot, D Baker… - Particle and fibre …, 2010 - Springer
Background Despite intensive research efforts, reports of cellular responses to
nanomaterials are often inconsistent and even contradictory. Additionally, relationships …
nanomaterials are often inconsistent and even contradictory. Additionally, relationships …
Cell death independent of caspases: a review
LE Broker, FAE Kruyt, G Giaccone - Clinical Cancer Research, 2005 - AACR
Patterns of cell death have been divided into apoptosis, which is actively executed by
specific proteases, the caspases, and accidental necrosis. However, there is now …
specific proteases, the caspases, and accidental necrosis. However, there is now …
Cathepsin D—many functions of one aspartic protease
P Benes, V Vetvicka, M Fusek - Critical reviews in oncology/hematology, 2008 - Elsevier
For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …
[HTML][HTML] Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response
Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …
Super-efficient in Vivo Two-Photon Photodynamic Therapy with a Gold Nanocluster as a Type I Photosensitizer
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic
technique that can induce the regression of targeted lesions via generating excess cytotoxic …
technique that can induce the regression of targeted lesions via generating excess cytotoxic …