The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer
ZY Shi, CY Li, RY Chen, JJ Shi, YJ Liu, JF Lu… - Bioorganic …, 2024 - Elsevier
Although certain members of the Ubiquitin-specific peptidases (USPs) have been
recognized as promising therapeutic targets for various diseases, research progress …
recognized as promising therapeutic targets for various diseases, research progress …
Discovery and characterization of BAY-805, a potent and selective inhibitor of ubiquitin-specific protease USP21
F Göricke, V Vu, L Smith, U Scheib… - Journal of Medicinal …, 2023 - ACS Publications
USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating
enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been …
enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been …
Building a Versatile Platform for the Detection of Protein–Protein Interactions Based on Organic Field-Effect Transistors
Detection and characterization of biomolecular interactions, such as protein–protein
interactions (PPIs), are critical to a fundamental understanding of biochemical processes …
interactions (PPIs), are critical to a fundamental understanding of biochemical processes …
Repurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: Computational modelling studies
MM Alshehri, AU Danazumi… - Journal of …, 2024 - Taylor & Francis
Abstract Ubiquitin specific protease 30 (USP30) has been attributed to mitochondrial
dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once …
dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once …
The multifaceted role of the ubiquitin proteasome system in pathogenesis and diseases
Ubiquitin is a small protein that is conjugated to target proteins to signal a great number of
critical biological processes. Impaired ubiquitin signaling and defects in the ubiquitin …
critical biological processes. Impaired ubiquitin signaling and defects in the ubiquitin …
[HTML][HTML] Inhibition of OTUB2 suppresses colorectal cancer cell growth by regulating β-Catenin signaling
X Xu, G Wu, K Han, X Cui, Y Feng, X Mei… - American Journal of …, 2023 - ncbi.nlm.nih.gov
In the effort to identify deubiquitinating enzymes required for the growth of colorectal cancer
(CRC) cells, we found that OTUB2 knockdown markedly inhibited the viability of these …
(CRC) cells, we found that OTUB2 knockdown markedly inhibited the viability of these …
Pharmacological and Structural Characterization of Zinc Finger Ubiquitin-Binding Domain Proteins
MK Mann - 2023 - search.proquest.com
Drug discovery is expensive, not only in terms of total cost but also in time. Approval of novel
compounds for therapeutic use is rare, often due to poor translation of pre-clinical findings to …
compounds for therapeutic use is rare, often due to poor translation of pre-clinical findings to …