Background Adequate antibiotic dosing may improve outcomes in critically ill patients but is
challenging due to altered and variable pharmacokinetics. To address this challenge …

Purpose: In the present narrative review, the authors aimed to discuss the relationship
between the pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics and clinical …

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent in vitro activity
and in vivo efficacy against most gram-negative bacteria, including carbapenem-resistant …

Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically
ventilated patients are limited. The present retrospective observational cohort study, which …

Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among
Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire …

Highlights•Augmented renal clearance (ARC) is a prevalent condition in the critically
ill.•ARC may result in sub-therapeutic exposure of renally eliminated antibiotics.•Beta …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …