Background Decreased serum albumin level (SAL) is associated with adverse clinical
outcomes. We designed the present study to further assess the prognostic value of SAL in …

The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

Background The prolonged β-lactam infusion strategy has emerged as the standard
treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess …

Aims The aim of the present study was to assess the pharmacokinetics of total and unbound
ceftriaxone in intensive care unit (ICU) patients and its protein binding characteristics …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …

Antimicrobial resistance (AMR) is a global health challenge that threatens humans, animals
and the environment. Evidence is emerging for a role of healthcare infrastructure …

Background Precision dosing programs are promising tools for optimising antimicrobial
dosing. Selecting the ideal program for local application may be challenging due to the large …