Therapeutic drug monitoring (TDM) of antibiotics has been practiced for more than half a
century, but it is still not widely applied for infected patients. It has a traditional focus on …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Objective: Dose optimization of novel β-lactam antibiotics (NBLA) has become necessary
given the increased prevalence of multidrug-resistant infections in intensive care units …

Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce …

Objective Unpredictable pharmacokinetics of antibiotics in patients with life-threatening
bacterial infections is associated with drug under-or overdosing. Therapeutic drug …

Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and
conduct of clinical pharmacology research in children. During drug development, PKPD …

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug‐resistant
Gram‐positive bacteria, especially methicillin‐resistant Staphylococcus aureus. In the last …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and
individualized treatment have been challenged since its approval. With the in-depth clinical …