Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

N Muvhulawa, PV Dludla, K Ziqubu… - Pharmacological …, 2022 - Elsevier
Chronic inflammation remains an essential complication in the pathogenesis and
aggravation of metabolic diseases. There is a growing interest in the use of medicinal plants …

[HTML][HTML] Dietary anti-aging polyphenols and potential mechanisms

J Luo, H Si, Z Jia, D Liu - Antioxidants, 2021 - mdpi.com
For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …

[HTML][HTML] Anti-obesity effects of metformin: a scoping review evaluating the feasibility of brown adipose tissue as a therapeutic target

K Ziqubu, SE Mazibuko-Mbeje, SXH Mthembu… - International Journal of …, 2023 - mdpi.com
Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to
promote energy expenditure and ameliorate diverse metabolic complications. There is a …

[HTML][HTML] Targeting the interplay of autophagy and ROS for cancer therapy: An updated overview on phytochemicals

L Dong, J He, L Luo, K Wang - Pharmaceuticals, 2023 - mdpi.com
Autophagy is an evolutionarily conserved self-degradation system that recycles cellular
components and damaged organelles, which is critical for the maintenance of cellular …

[HTML][HTML] A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

FT Mthiyane, PV Dludla, K Ziqubu… - Frontiers in …, 2022 - frontiersin.org
Moringa oleifera is one of the popular plants that have shown significant health benefits.
Certainly, preclinical evidence (predominantly from animal models) summarized in the …

Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway

S Feng, Y Li, H Huang, H Huang, Y Duan… - European Journal of …, 2023 - Elsevier
Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Z Liang, A Currais, D Soriano-Castell… - Pharmacology & …, 2021 - Elsevier
Mitochondria are the primary source of energy production in the brain thereby supporting
most of its activity. However, mitochondria become inefficient and dysfunctional with age and …

[HTML][HTML] Natural compounds: a potential treatment for alcoholic liver disease?

J Yan, Y Nie, M Luo, Z Chen, B He - Frontiers in pharmacology, 2021 - frontiersin.org
Excessive alcohol intake is a direct cause of alcoholic liver disease (ALD). ALD usually
manifests as fatty liver in the initial stage and then develops into alcoholic hepatitis (ASH) …

A review of plant antipathogenic constituents: Source, activity and mechanism

Y Wang, Y Xu, Z Liu - Pesticide Biochemistry and Physiology, 2022 - Elsevier
Green prevention and control of plant pathogens is a development direction of sustainable
and low-carbon agriculture given the limitation of traditional chemicals. Plant-derived …

Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways

S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …