Health benefits of polyphenols: A concise review

A Rana, M Samtiya, T Dhewa, V Mishra… - Journal of Food …, 2022 - Wiley Online Library
Plants produce polyphenols, which are considered highly essential functional foods in our
diet. They are classified into several groups according to their diverse chemical structures …

The interaction of polyphenols and the gut microbiota in neurodegenerative diseases

Y Zhang, W Yu, L Zhang, M Wang, W Chang - Nutrients, 2022 - mdpi.com
Polyphenols are secondary metabolites of plants and play a potential role in the prevention
and treatment of neurodegenerative diseases (NND) such as Alzheimer's disease (AD) and …

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Neurodevelopmental toxicity induced by PM2. 5 Exposure and its possible role in Neurodegenerative and mental disorders

X Liu, J Huang, C Song, T Zhang… - Human & …, 2023 - journals.sagepub.com
Recent extensive evidence suggests that ambient fine particulate matter (PM2. 5, with an
aerodynamic diameter≤ 2.5 μm) may be neurotoxic to the brain and cause central nervous …

Advances in polyphenol-based carbon dots for biomedical engineering applications

J Han, J Hong, H Lee, S Choi, K Shin, M Gu… - European Polymer …, 2023 - Elsevier
Polyphenol-based carbon dots (PCDs) are a promising class of nanomaterials that have
been increasingly studied for their potential applications in biomedical engineering. PCDs …

Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review

S Fakhri, SZ Moradi, A Ash-Rafzadeh… - Pharmacological …, 2022 - Elsevier
Senescence suppresses tumor growth, while also developing a tumorigenic state in the
nearby cells that is mediated by senescence-associated secretory phenotypes (SASPs). The …

Targeting mitochondrial dysfunction in neurodegenerative diseases: expanding the therapeutic approaches by plant-derived natural products

X Zhang, L Wang, B Li, J Shi, J Xu, M Yuan - Pharmaceuticals, 2023 - mdpi.com
Mitochondria are the primary source of energy production in neurons, supporting the high
energy consumption of the nervous system. Inefficient and dysfunctional mitochondria in the …

Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic …

M Ayaz, OF Mosa, A Nawaz, AAE Hamdoon… - Phytomedicine, 2024 - Elsevier
Background Alzheimer's diseases (AD) and dementia are among the highly prevalent
neurological disorders characterized by deposition of beta amyloid (Aβ) plaques, dense …

Modulation of TLR/NF-κB/NLRP signaling by bioactive phytocompounds: A promising strategy to augment cancer chemotherapy and immunotherapy

S Fakhri, SZ Moradi, A Yarmohammadi… - Frontiers in …, 2022 - frontiersin.org
Background Tumors often progress to a more aggressive phenotype to resist drugs. Multiple
dysregulated pathways are behind this tumor behavior which is known as cancer …

Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects

T Wang, H Xu, R Dong, S Wu, Y Guo… - Food Research …, 2023 - Elsevier
Globally, inflammation and metabolic disorders pose serious public health problems and are
major health concerns. It has been shown that natural polyphenols are effective in the …