[HTML][HTML] AMPK, mitochondrial function, and cardiovascular disease

S Wu, MH Zou - International journal of molecular sciences, 2020 - mdpi.com
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction: a systematic review and …

YS Hamirani, A Wong, CM Kramer… - JACC: Cardiovascular …, 2014 - jacc.org
The goal of this systematic analysis is to provide a comprehensive review of the current
cardiac magnetic resonance data on microvascular obstruction (MVO) and intramyocardial …

[HTML][HTML] Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: a mechanism involving calcium overload/XO/ROS/mPTP pathway

P Zhu, S Hu, Q Jin, D Li, F Tian, S Toan, Y Li, H Zhou… - Redox biology, 2018 - Elsevier
Abstract Receptor-interacting protein 3 (Ripk3)-mediated necroptosis contributes to cardiac
ischaemia-reperfusion (IR) injury through poorly defined mechanisms. Our results …

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission‐VDAC 1‐HK 2‐mPTP‐mitophagy axis

H Zhou, Y Zhang, S Hu, C Shi, P Zhu… - Journal of pineal …, 2017 - Wiley Online Library
The cardiac microvascular system, which is primarily composed of monolayer endothelial
cells, is the site of blood supply and nutrient exchange to cardiomyocytes. However …

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated …

H Zhou, S Hu, Q Jin, C Shi, Y Zhang, P Zhu… - Journal of the …, 2017 - Am Heart Assoc
Background The cardiac microvascular system ischemia/reperfusion injury following
percutaneous coronary intervention is a clinical thorny problem. This study explores the …

Exosomal circHIPK3 released from hypoxia‐pretreated cardiomyocytes regulates oxidative damage in cardiac microvascular endothelial cells via the miR‐29a/IGF‐1 …

Y Wang, R Zhao, W Liu, Z Wang, J Rong… - Oxidative medicine …, 2019 - Wiley Online Library
Background/Aims. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs
that regulate gene expression in eukaryotes. Recently, exosomes from cardiomyocytes …

BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk–Nox2–Drp1-mitochondrial fission pathways

H Zhou, C Shi, S Hu, H Zhu, J Ren, Y Chen - Angiogenesis, 2018 - Springer
Background Mitochondrial fission has been identified as the pathogenesis underlying the
development of cardiac microvascular ischemia reperfusion (IR) injury, although the …

Postinfarct left ventricular remodelling: a prevailing cause of heart failure

A Galli, F Lombardi - Cardiology research and practice, 2016 - Wiley Online Library
Heart failure is a chronic disease with high morbidity and mortality, which represents a
growing challenge in medicine. A major risk factor for heart failure with reduced ejection …

[HTML][HTML] CMR of microvascular obstruction and hemorrhage in myocardial infarction

KC Wu - Journal of Cardiovascular Magnetic Resonance, 2012 - Elsevier
Microvascular obstruction (MO) or no-reflow phenomenon is an established complication of
coronary reperfusion therapy for acute myocardial infarction. It is increasingly recognized as …

Long-term incremental prognostic value of cardiovascular magnetic resonance after ST-segment elevation myocardial infarction: a study of the collaborative registry …

R Symons, G Pontone, J Schwitter, M Francone… - JACC: Cardiovascular …, 2018 - jacc.org
Objectives: This study sought to investigate whether early post-infarction cardiac magnetic
resonance (CMR) parameters provide additional long-term prognostic value beyond …