From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia

P Abrisqueta, F Nadeu, J Bosch-Schips… - Cancer Treatment …, 2023 - Elsevier
Richter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the
most prevalent leukemia among adults, into a highly aggressive lymphoproliferative …

Histiocytic and dendritic cell sarcomas of hematopoietic origin share targetable genomic alterations distinct from follicular dendritic cell sarcoma

LR Massoth, YP Hung, JA Ferry, RP Hasserjian… - The …, 2021 - academic.oup.com
Background Histiocytic and dendritic cell neoplasms are a diverse group of tumors arising
from monocytic or dendritic cell lineage. Whereas the genomic features for Langerhans cell …

[HTML][HTML] Pediatric lymphoid and histiocytic lesions in the head and neck

A Auerbach, JJ Schmieg, NS Aguilera - Head and Neck Pathology, 2021 - Springer
Lymphoid and histiocytic lesions of the head and neck in pediatric patients is a fascinating
topic as most of these lesions are benign, but that the neoplastic cases are essential to …

[HTML][HTML] Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

JM Evans, HG Parker, GR Rutteman, J Plassais… - PLoS …, 2021 - journals.plos.org
Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes
with a poorly understood etiology in humans. A histologically and clinically similar …

Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma

JA Lenz, CA Assenmacher, V Costa, K Louka… - Cancer Immunology …, 2022 - Springer
Histiocytic sarcoma (HS) is a rare and aggressive tumor in humans with no universally
agreed standard of care therapy. Spontaneous canine HS exhibits increased prevalence in …

[HTML][HTML] Application of PD‑L1 blockade in refractory histiocytic sarcoma: A case report

O Imataki, M Uemura, H Fujita… - Molecular and …, 2022 - spandidos-publications.com
Histiocytic sarcoma (HS) is a rare hematological malignancy, which exhibits morphological
and immunophenotypic features of histiocytes. A standard therapy for HS has not yet been …

[HTML][HTML] Case report: Targeting the PD-1 receptor and genetic mutations validated in primary histiocytic sarcoma with hemophagocytic lymphohistiocytosis

Y Zhao, Y Deng, Y Jiang, W Zheng, Y Tan… - Frontiers in …, 2023 - frontiersin.org
Histiocytic sarcoma (HS) is a rare hematological malignancy with limited treatment options,
and it is also prone to complications such as hemophagocytic lymphohistiocytosis (HLH) in …

Identification of aspartame-induced haematopoietic and lymphoid tumours in rats after lifetime treatment

E Tibaldi, F Gnudi, S Panzacchi, D Mandrioli, A Vornoli… - Acta histochemica, 2020 - Elsevier
Lymphomas and leukaemias involving the lung have in some cases been hard to
distinguish from respiratory tract infection in Sprague-Dawley (SD) rats from long-term …

[HTML][HTML] Sirolimus as frontline therapy for PTEN-mutated histiocytic sarcoma

KL Chohan, JP Abeykoon, JR Young, WO Tobin… - …, 2023 - ncbi.nlm.nih.gov
Histiocytic sarcoma (HS) is an extremely rare non-Langerhans histiocytic neoplasm that can
present as unifocal or multifocal extranodal disease. 1 The limited reports available for this …

Controversies in the Spleen: Histiocytic, Dendritic, and Stromal Cell Lesions

A Auerbach, M Girton… - Surgical Pathology …, 2023 - surgpath.theclinics.com
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