Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for~ 5%
of global disease burden. A minority of people with recreational alcohol use develop alcohol …

Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …

Poorly regulated reward seeking is a central feature of substance use disorder. Recent
research shows that rewarding drug-related experiences induce synchronous activation of a …

Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring
adaptation of behavior to changing information from external and internal sources. However …

The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as
reward seeking and flexible decision making. However, the precise nature of its role in these …

Decision-making involves multiple cognitive processes requiring different aspects of
information about the situation at hand. The rodent medial prefrontal cortex (mPFC) has …

Activity in numerous brain regions drives heroin seeking, but no circuits that limit heroin
seeking have been identified. Furthermore, the neural circuits controlling opioid choice are …

Neuronal ensembles in ventromedial prefrontal cortex (vmPFC) play a role in both cocaine
and palatable food seeking. However, it is unknown whether similar or different vmPFC …

Neuronal ensembles are local, sparsely distributed populations of neurons that are reliably
re-activated by a specific stimulus, context or task. Such discrete cell populations can be …