[HTML][HTML] Neurogenic inflammation: the participant in migraine and recent advancements in translational research

E Spekker, M Tanaka, Á Szabó, L Vécsei - Biomedicines, 2021 - mdpi.com
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

[HTML][HTML] An overview of animal models of pain: disease models and outcome measures

NS Gregory, AL Harris, CR Robinson, PM Dougherty… - The journal of pain, 2013 - Elsevier
Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Perineural invasion and associated pain in pancreatic cancer

AA Bapat, G Hostetter, DD Von Hoff, H Han - Nature Reviews Cancer, 2011 - nature.com
Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …

Unravelling the mystery of capsaicin: a tool to understand and treat pain

J O'Neill, C Brock, AE Olesen, T Andresen… - Pharmacological …, 2012 - ASPET
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

Why do cannabinoid receptors have more than one endogenous ligand?

V Di Marzo, L De Petrocellis - … Transactions of the …, 2012 - royalsocietypublishing.org
The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …

TRP channels: a journey towards a molecular understanding of pain

T Rosenbaum, SL Morales-Lázaro… - Nature Reviews …, 2022 - nature.com
The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

[HTML][HTML] Molecular targets of cannabidiol in experimental models of neurological disease

S Silvestro, G Schepici, P Bramanti, E Mazzon - Molecules, 2020 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

A Nieto-Posadas, G Picazo-Juárez, I Llorente… - Nature chemical …, 2012 - nature.com
Since 1992, there has been growing evidence that the bioactive phospholipid
lysophosphatidic acid (LPA), whose amounts are increased upon tissue injury, activates …

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

RB Singh, A Naderi, W Cho, G Ortiz, A Musayeva… - The ocular …, 2022 - Elsevier
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …

[HTML][HTML] Specialized pro-resolving lipid mediators: the future of chronic pain therapy?

M Chávez-Castillo, Á Ortega, L Cudris-Torres… - International journal of …, 2021 - mdpi.com
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …