[HTML][HTML] Neurogenic inflammation: the participant in migraine and recent advancements in translational research
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …
[HTML][HTML] An overview of animal models of pain: disease models and outcome measures
NS Gregory, AL Harris, CR Robinson, PM Dougherty… - The journal of pain, 2013 - Elsevier
Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …
Perineural invasion and associated pain in pancreatic cancer
Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …
Unravelling the mystery of capsaicin: a tool to understand and treat pain
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …
physiological systems, with an emphasis on pain research but also including functions such …
Why do cannabinoid receptors have more than one endogenous ligand?
V Di Marzo, L De Petrocellis - … Transactions of the …, 2012 - royalsocietypublishing.org
The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …
TRP channels: a journey towards a molecular understanding of pain
T Rosenbaum, SL Morales-Lázaro… - Nature Reviews …, 2022 - nature.com
The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …
role in the survival of organisms. Because pain is linked to a negative sensation, animals …
[HTML][HTML] Molecular targets of cannabidiol in experimental models of neurological disease
S Silvestro, G Schepici, P Bramanti, E Mazzon - Molecules, 2020 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …
Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site
A Nieto-Posadas, G Picazo-Juárez, I Llorente… - Nature chemical …, 2012 - nature.com
Since 1992, there has been growing evidence that the bioactive phospholipid
lysophosphatidic acid (LPA), whose amounts are increased upon tissue injury, activates …
lysophosphatidic acid (LPA), whose amounts are increased upon tissue injury, activates …
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …
systems. SP is predominantly released by neurons and exerts its biological and …
[HTML][HTML] Specialized pro-resolving lipid mediators: the future of chronic pain therapy?
M Chávez-Castillo, Á Ortega, L Cudris-Torres… - International journal of …, 2021 - mdpi.com
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …
consequences for patients, which can occur in a myriad of diseases. Often, conventional …