Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

There is a widely recognized need to improve the performance of vascular implants and
external medical devices that come into contact with blood by reducing adverse reactions …

The marginal band of microtubules maintains the discoid shape of resting blood platelets.
Although studies of platelet microtubule coil structure conclude that it is composed of a …

The therapeutic basis of platelet-rich plasma use in medicine is derived from the growth
factor content and provisional matrix provided by the platelets themselves. This chapter …

Background—A prior study from the Veterans Health Administration found a clustering of
cardiovascular events after clopidogrel cessation. We sought to confirm and expand these …

Protein glycosylation, including sialylation, involves complex and frequent post-translational
modifications, which play a critical role in different biological processes. The conjugation of …

BACKGROUND Platelet‐derived extracellular vesicles (PL‐EVs) are present in
plateletpheresis concentrates (PCs) and may influence the quality of PCs. The aim of the …

BACKGROUND: A hallmark of platelet (PLT) storage lesion is the loss of PLT lipids. Due to
technical limitations a detailed lipidomic analysis of plateletpheresis products during storage …

Platelets play a pivotal role in primary hemostasis where their rapid response to vascular
injury prevents excessive bleeding. To accomplish this, platelets are enriched in membrane …

Background: The efficacy of thrombopoietin (TPO) mimetics in patients with idiopathic
thrombocytopenic purpura (ITP) reaffirms that impaired platelet production is an important …