Over the past two decades, small noncoding RNAs (sRNAs) that regulate mRNAs by short
base pairing have gone from a curiosity to a major class of post-transcriptional regulators in …

Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …

Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes
from viral (phage) attack through the production of cyclic oligonucleotides, which activate …

The extracellular matrix of bacterial biofilms consists of diverse components including
polysaccharides, proteins and DNA. Extracellular RNA (eRNA) can also be present …

Species loss within a microbial community can increase resource availability and spur
adaptive evolution. Environmental shifts that cause species loss or fluctuations in community …

The vast majority of genomic sequences are automatically annotated using various software
programs. The accuracy of these annotations depends heavily on the very few manual …

Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

CRISPR-Cas systems provide prokaryotes with acquired immunity against viruses and
plasmids, but how these systems are regulated to prevent autoimmunity is poorly …

Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the
most abundant regulatory motif known to biology. Frequently reported for transcriptional …

NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus
subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the …