Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

P Coghi, J Li, NS Hosmane… - Medicinal Research …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) is one of the most promising treatments among
neutron capture therapies due to its long‐term clinical application and unequivocally …

Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging

S Scaramuzza, CMG De Faria… - Advanced Functional …, 2023 - Wiley Online Library
New multifunctional theranostic vectors allow the expansion of cancer therapeutic
approaches toward scarcely investigated fields. One example is the combination of boron …

Enriched 10B-diboron reagents synthesis from 10BF3

D Chen, L Xu, Z Wang, C Liu - Chem, 2023 - cell.com
Stable isotopes have become vital tools in drug development and discovery. Because of the
unique high neutron absorption properties of boron-10, boron neutron capture therapy …

Recent Development of Radiofluorination of Boron Agents for Boron Neutron Capture Therapy of Tumor: Creation of 18F-Labeled CF and BF Linkages

JP Deng, CS Yu - Pharmaceuticals, 2023 - mdpi.com
Boron neutron capture therapy (BNCT) is a binary therapeutic technique employing a boron
agent to be delivered to the tumor site followed by the irradiation of neutrons. Biofunctional …

In Vivo Application of Carboranes for Boron Neutron Capture Therapy (BNCT): Structure, Formulation and Analytical Methods for Detection

TD Marforio, A Carboni, M Calvaresi - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is an emerging anticancer
treatment. The success of BNCT relies on the delivery of adequate quantities of 10B to tumor …

Animal tumor models for boron neutron capture therapy studies (excluding central nervous system solid tumors)

A Monti Hughes, AE Schwint - Cancer Biotherapy & …, 2022 - liebertpub.com
Translational research in adequate experimental models is necessary to optimize boron
neutron capture therapy (BNCT) for different pathologies. Multiple radiobiological in vivo …

Nanostructured boron agents for boron neutron capture therapy: a review of recent patents

X Zhang, Y Lin, NS Hosmane, Y Zhu - Medical Review, 2023 - degruyter.com
Boron neutron capture therapy (BNCT) is a potential radiation therapy modality for cancer,
and tumor-targeted stable boron-10 (10B) delivery agents are an important component of …

[HTML][HTML] Targeting the organelle for radiosensitization in cancer radiotherapy

X Sun, L Wu, L Du, W Xu, M Han - Asian Journal of Pharmaceutical …, 2024 - Elsevier
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-
energy ionizing radiation to destroy cancer cells. However, this method has several …

Fluorine-18 labeling PEGylated 6-boronotryptophan for PET scanning of mice for assessing the pharmacokinetics for boron neutron capture therapy of brain tumors

XP Chen, FC Hsu, KY Huang, TS Hsieh, SS Farn… - Bioorganic & Medicinal …, 2024 - Elsevier
Two tryptophan compound classes 5-and 6-borono PEGylated boronotryptophan derivatives
have been prepared for assessing their aqueous solubility as formulation of injections for …