Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
[HTML][HTML] Improving clinical trial outcomes in amyotrophic lateral sclerosis
Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …
historically intransigent problem that has existed since the initial description of the disease in …
Safety and effectiveness of long-term intravenous administration of edaravone for treatment of patients with amyotrophic lateral sclerosis
Importance Intravenous edaravone is approved as a disease-modifying drug for patients
with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term …
with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term …
Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
[HTML][HTML] Current state and future directions in the therapy of ALS
L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
[HTML][HTML] New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022
JS Jiang, Y Wang, M Deng - Frontiers in pharmacology, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that
primarily affects motor neurons in the brain and spinal cord. In the recent past, there have …
primarily affects motor neurons in the brain and spinal cord. In the recent past, there have …
[HTML][HTML] Intravenous edaravone treatment in ALS and survival: An exploratory, retrospective, administrative claims analysis
BR Brooks, JD Berry, M Ciepielewska, Y Liu… - …, 2022 - thelancet.com
Background We aimed to evaluate overall survival in US patients with amyotrophic lateral
sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated …
sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated …
[HTML][HTML] SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective
C Wong, M Stavrou, E Elliott, JM Gregory… - Brain …, 2021 - academic.oup.com
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease.
Despite decades of clinical trials, effective disease-modifying drugs remain scarce. To …
Despite decades of clinical trials, effective disease-modifying drugs remain scarce. To …
Oral edaravone–introducing a flexible treatment option for amyotrophic lateral sclerosis
GL Pattee, A Genge, P Couratier… - Expert Review of …, 2023 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive and incurable
neurodegenerative disease. While pharmacotherapy options remain limited, the Food and …
neurodegenerative disease. While pharmacotherapy options remain limited, the Food and …