Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

G Poli, A Kinter, JS Justement… - Proceedings of the …, 1990 - National Acad Sciences
Tumor necrosis factor alpha (TNF-alpha) is an immunoregulatory cytokine capable of
inducing viral expression in cells chronically infected with the human immunodeficiency …

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1 …

RI Connor, H Mohri, Y Cao, DD Ho - Journal of virology, 1993 - Am Soc Microbiol
The rate of clinical progression is variable among individuals infected with human
immunodeficiency virus type 1 (HIV-1). Changes in viral burden which correlate with disease …

[PDF][PDF] Tendências da epidemia de Aids no Brasil após a terapia anti-retroviral

I Dourado, MASM Veras, D Barreira… - Revista de Saúde …, 2006 - SciELO Public Health
OBJETIVO: A terapia anti-retroviral disponível no Brasil a partir de 1996, modificou o curso
da epidemia de Aids, alterando sua evolução e tendências. Nesse sentido, o estudo teve …

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

RJ Pomerantz, D Trono, MB Feinberg, D Baltimore - Cell, 1990 - Elsevier
U1 and ACH-2 cells are subclones of HIV-1-infected monocyte/macrophage-like and T
lymphocyte cell lines, respectively, which express the HIV-1 genome at very low levels. We …

Apoptosis in AIDS

ML Gougeon, L Montagnier - Science, 1993 - science.org
The authors are in the Department of AIDSand Retroviruses, Institut Pasteur, 28rue du Dr.
Roux, 75724 Paris Cedex, France. that programmed cell death induction is related to AIDS …

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

H Soudeyns, XI Yao, Q Gao, B Belleau… - Antimicrobial agents …, 1991 - Am Soc Microbiol
We describe a novel nucleoside analog, 2'-deoxy-3'-thiacytidine (BCH-189), in which the
3'carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom. In MT-4 T …

Multiple functional domains of Tat, the trans -activator of HIV-1, defined by mutational analysis

M Kuppuswamy, T Subramanian… - Nucleic acids …, 1989 - academic.oup.com
The tat gene of HIV-1 is a potent trans-activator of gene expression from the HIV long
terminal repeat (LTR). To define the functionally important regions of the product of the tat …

Fidelity of HIV-1 reverse transcriptase copying RNA in vitro

J Ji, LA Loeb - Biochemistry, 1992 - ACS Publications
Materials and Methods Bacteria and Bacteriophage. Escherichia coli MCI061 [hsdR, mcrB,
araD, 139A-(araABC-leu), 7679AlacX74, galU, galK, rpsL, thi] was the transformation host …

Species-specific, postentry barriers to primate immunodeficiency virus infection

W Hofmann, D Schubert, J LaBonte, L Munson… - Journal of …, 1999 - Am Soc Microbiol
By using replication-defective vectors derived from human immunodeficiency virus type 1
(HIV-1), simian immunodeficiency virus (SIVmac), and murine leukemia virus (MuLV), all of …

The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection

S Bour, R Geleziunas, MA Wainberg - Microbiological reviews, 1995 - Am Soc Microbiol
Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …