Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

MR guided radiotherapy represents one of the most promising recent technological
innovations in the field. The possibility to better visualize therapy volumes, coupled with the …

Chimeric antigen receptor (CAR)-T cells have demonstrated significant improvements in the
treatment of refractory B-cell malignancies that previously showed limited survival. In …

Objectives Hypoxia is associated with poor prognosis and treatment resistance in breast
cancer. However, the temporally variant nature of hypoxia can complicate interpretation of …

Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical
and potential therapeutic benefits as compared to conventional radiotherapy. However, its …

Simple Summary Pancreatic cancer is characterized by a dense network of connective
tissue surrounding clusters of cancer cells, the so-called stroma. This ubiquitous connective …

Dose painting of hypoxic tumour sub-volumes using positron-emission tomography (PET)
has been shown to improve tumour control in silico in several sites, predominantly head and …

Stereotactic body radiation therapy (SBRT) has shown promising results in the treatment of
pancreatic cancer and other solid tumors. However, wide adoption of SBRT remains limited …

Fractionated radiotherapy was established in the 1920s based upon two principles:(1)
delivering daily treatments of equal quantity, unless the clinical situation requires …