[HTML][HTML] Mitochondria-derived peptides in aging and healthspan
The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …
be studied, but one element has been unexplored: microproteins. Small open reading …
Mitochondrial proteome research: the road ahead
ZN Baker, P Forny, DJ Pagliarini - Nature Reviews Molecular Cell …, 2024 - nature.com
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …
Mitochondrial-derived peptides in energy metabolism
TL Merry, A Chan, JST Woodhead… - American Journal …, 2020 - journals.physiology.org
Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by short open-
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
[HTML][HTML] The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Humanin is a member of a new family of peptides that are encoded by short open reading
frames within the mitochondrial genome. It is conserved in animals and is both …
frames within the mitochondrial genome. It is conserved in animals and is both …
Towards a unified mechanistic theory of aging
G Barja - Experimental gerontology, 2019 - Elsevier
A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …
are highly conserved during evolution from yeast and invertebrates to mammals. Many …
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE
Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
[HTML][HTML] Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging
M Conte, J Sabbatinelli, A Chiariello, M Martucci… - Geroscience, 2021 - Springer
Abstract Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF15), and
Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease …
Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease …
[HTML][HTML] Humanin and its pathophysiological roles in aging: A systematic review
D Coradduzza, A Congiargiu, Z Chen, S Cruciani… - Biology, 2023 - mdpi.com
Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …
number of potential therapeutic applications for various age-related diseases. It plays an …
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway
Y Wang, N Li, Z Zeng, L Tang, S Zhao… - Molecular Human …, 2021 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among
women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic …
women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic …