The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell …

Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked
clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and …

Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation,
dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose …

Simple Summary Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. It
belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule …

Chemotherapy—induced gastrointestinal dysfunction is a common occurrence associated
with many different classes of chemotherapeutic agents. Gastrointestinal toxicity includes …

Low muscle mass is prevalent among patients with cancer and a predictor of adverse
clinical outcomes. To counteract muscle loss, β‐hydroxy β‐methylbutyrate (HMB) …

Regulated cell death is an integral part of life, and has broad effects on organism
development and homeostasis. Malfunctions within the regulated cell death process …