Schizophrenia is a neurodevelopmental disorder that starts very early. In this review we
describe the empirical evidence for the neurodevelopmental model. First, by outlining the …

Objective: At first hospitalization, a long duration of untreated psychosis (DUP) predicts
illness severity and worse treatment outcomes. The mechanism of this association, however …

Background Cognitive impairment is a core feature of schizophrenia, associated with poor
functional outcomes. The course of cognitive function in the years following illness onset has …

Background There is a large variability in the recovery trajectory and outcome of first
episode of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage …

Background: Roughly 30% of schizophrenia patients fail to respond to at least two
antipsychotic trials. Psychosis has been traditionally considered to be poorly sensitive to …

Background Individuals with schizophrenia exhibit marked and disproportional impairment
in social cognition, which is associated with their level of community functioning. However, it …

Although cognitive impairments are consistently linked to functional outcome in chronic
schizophrenia, the relationship remains unclear for patients with first-episode schizophrenia …

Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to
their presence throughout different illness stages and their impact on functioning …

Methods Participants in the COGS-2 study have previously been described, including
inclusion and exclusion criteria (29). Participants were either healthy control subjects (HCS …

Little is known about long-term outcomes of the first episode of psychosis (FEP) other than in
the symptomatic domain. We hypothesised that cognitive impairment is associated with …