Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Estrogens and phytoestrogens in body functions

I Ceccarelli, L Bioletti, S Peparini, E Solomita… - Neuroscience & …, 2022 - Elsevier
Estrogens are the hormones of reproduction in women as well as of many other important
functions in the male and female body. They undergo significant changes in the different …

Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis

Y Wu, X Liu, G Li - Scientific reports, 2022 - nature.com
Huangqin decoction (HQD) is a Traditional Chinese Medicine formula for ulcerative colitis.
However, the pharmacology and molecular mechanism of HQD on ulcerative colitis is still …

[HTML][HTML] Estrogen plays an important role by influencing the NLRP3 inflammasome

W Dong, Q Peng, Z Liu, Z Xie, X Guo, Y Li… - Biomedicine & …, 2023 - Elsevier
The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

Sex-related differences in inflammatory bowel diseases: the potential role of sex hormones

L Xu, G Huang, Y Cong, Y Yu, Y Li - Inflammatory bowel …, 2022 - academic.oup.com
Inflammatory bowel disease (IBD), characterized by chronic inflammation of the
gastrointestinal tract, is a global health care problem. Compelling evidence shows sex …

[HTML][HTML] Sex difference of colon adenoma pathway and colorectal carcinogenesis

Y Choi, N Kim - The World Journal of Men's Health, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …

Gender differences in psychological symptoms and quality of life in patients with inflammatory bowel disease in China: a multicenter study

C Liu, J Zhang, M Chen, P An, J Xiang, R Yu… - Journal of Clinical …, 2023 - mdpi.com
Objective: To explore the gender differences in the psychological symptoms, sleep quality,
and quality of life of patients with inflammatory bowel disease (IBD). Methods: A unified …

Paris polyphylla extract attenuates colitis in mice by regulating PPAR-γ mediated Treg/Th17 balance

L He, X Yan, S Wen, Z Zhong, Z Hou, F Liu… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Paris polyphylla Sm.(PP), is a widely-used
traditional Chinese medicine (TCM) in the treatment of wound, throat sores and snakebites …

Significance of G protein-coupled estrogen receptor in the pathophysiology of irritable bowel syndrome, inflammatory bowel diseases and colorectal cancer

D Jacenik, WM Krajewska - Frontiers in Endocrinology, 2020 - frontiersin.org
The regulatory role of estrogens and nuclear estrogen receptors, ie, estrogen receptor α and
β has been reported in gastrointestinal diseases. However, the contribution of G protein …

Estrogen receptor actions in colitis

EL Garcia-Villatoro, CD Allred - Essays in Biochemistry, 2021 - portlandpress.com
In recent years, researchers have demonstrated that estrogen and its receptors, aside from
their role in regulating several biological functions, contribute to the development and …