[HTML][HTML] Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

[HTML][HTML] The G protein-coupled oestrogen receptor GPER in health and disease: an update

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

[HTML][HTML] G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications

JB Arterburn, ER Prossnitz - Annual review of pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

[HTML][HTML] Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

JY Li, B Chassaing, AM Tyagi… - The Journal of …, 2016 - Am Soc Clin Investig
A eubiotic microbiota influences many physiological processes in the metazoan host,
including development and intestinal homeostasis. Here, we have shown that the intestinal …

[HTML][HTML] The roles of estrogen and estrogen receptors in gastrointestinal disease

C Chen, X Gong, X Yang, X Shang… - Oncology …, 2019 - spandidos-publications.com
Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

[HTML][HTML] G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

D Jacenik, EJ Beswick, WM Krajewska… - World Journal of …, 2019 - ncbi.nlm.nih.gov
Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Bone remodeling and the microbiome

R Pacifici - Cold Spring Harbor perspectives in …, 2018 - perspectivesinmedicine.cshlp.org
Exposed surfaces of mammals are colonized with 100 trillion indigenous bacteria, fungi, and
viruses, creating a diverse ecosystem known as the microbiome. The gastrointestinal tract …

[HTML][HTML] Sex-bias in irritable bowel syndrome: linking steroids to the gut-brain axis

SY So, TC Savidge - Frontiers in Endocrinology, 2021 - frontiersin.org
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is more common
in females. Despite its high global incidence, the disease mechanism is still unclear and …

Osteomicrobiology: The influence of gut microbiota on bone in health and disease

RM Jones, JG Mulle, R Pacifici - Bone, 2018 - Elsevier
Host cell and microbe interactions have evolved in practically every animal, with the cross-
talk between microorganisms that inhabit the gut lumen with tissues of the gastrointestinal …

[HTML][HTML] Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an …

G Chen, H Zeng, X Li, J Liu, Z Li, R Xu, Y Ma… - Cell death & …, 2021 - nature.com
Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to
antineoplastic treatment with few appropriate, specific interventions. We aimed to identify the …