The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …

Liver diseases, characterized by high morbidity and mortality, represent a substantial
medical problem globally. The current therapeutic approaches are mainly aimed at reducing …

Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and
internal organs. Protein tyrosine phosphatases have received little attention in the study of …

Phosphatases of regenerating liver (PRLs) are protein phosphatases involved in the control
of cell growth and migration. They are known to promote cancer metastasis but, despite over …

Phosphatase of regenerating liver 3 (PRL-3) is associated with cancer metastasis and has
been shown to interact with the cyclin and CBS domain divalent metal cation transport …

Protein tyrosine phosphatases are essential modulators of angiogenesis and have been
identified as novel therapeutic targets in cancer and anti-angiogenesis. The roles of atypical …

Abstract Magnesium (Mg 2+) plays pleiotropic roles in cellular biology, and it is essentially
required for all living organisms. Although previous studies demonstrated intracellular Mg 2+ …

The PRL phosphatases are oncogenic when overexpressed but their in vivo biological
function is less well understood. Previous gene deletion study revealed a role for PRL2 in …

The family of protein tyrosine phosphatases (PTPs) includes 107 genes in humans that are
diverse in their structures and expression profiles. The majority are present in immune cells …