[HTML][HTML] Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients
R Bellmann, P Smuszkiewicz - Infection, 2017 - Springer
Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …
Therapeutic drug monitoring of anti-infective agents in critically ill patients
NGL Jager, RM van Hest, J Lipman… - Expert review of …, 2016 - Taylor & Francis
Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …
outcomes for patients with severe infections. However, in critically ill patients, several …
Observational study of the clinical efficacy of voriconazole and its relationship to plasma concentrations in patients
Voriconazole is approved for treating invasive fungal infections. We examined voriconazole
exposure-response relationships for patients from nine published clinical trials. The …
exposure-response relationships for patients from nine published clinical trials. The …
Voriconazole pharmacokinetics and pharmacodynamics in children
Background Voriconazole pharmacokinetic and pharmacodynamic data are lacking in
children. Methods Records at the Childrens Hospital Los Angeles were reviewed for …
children. Methods Records at the Childrens Hospital Los Angeles were reviewed for …
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations
Therapeutic drug monitoring (TDM) may be required to achieve optimal clinical outcomes in
the setting of significant pharmacokinetic variability, a situation that applies to a number of …
the setting of significant pharmacokinetic variability, a situation that applies to a number of …
Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis
KE Stott, H Pertinez, MGG Sturkenboom… - Journal of …, 2018 - academic.oup.com
Objectives The objectives of this study were to explore inter-study heterogeneity in the
pharmacokinetics (PK) of orally administered rifampicin, to derive summary estimates of …
pharmacokinetics (PK) of orally administered rifampicin, to derive summary estimates of …
Overview of antifungal agents
GR Thompson, J Cadena… - Clinics in chest …, 2009 - chestmed.theclinics.com
The number of agents available to treat fungal infections has increased by 30% since the
year 2000, yet still only 15 agents are currently approved for clinical use. The greater …
year 2000, yet still only 15 agents are currently approved for clinical use. The greater …
Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring
MJ Dolton, JE Ray, D Marriott… - Antimicrobial agents and …, 2012 - Am Soc Microbiol
Posaconazole has become an important part of the antifungal armamentarium in the
prophylaxis and salvage treatment of invasive fungal infections (IFIs). Structurally related to …
prophylaxis and salvage treatment of invasive fungal infections (IFIs). Structurally related to …
Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations
J Walravens, J Brouwers, I Spriet, J Tack… - Clinical …, 2011 - Springer
Abstract Background and Objective: Posaconazole (Noxafil®) is an extended-spectrum
triazole antifungal agent for prevention and treatment of invasive fungal infections. An …
triazole antifungal agent for prevention and treatment of invasive fungal infections. An …
Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole …
LA Decosterd, B Rochat, B Pesse… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Therapeutic drug monitoring (TDM) may contribute to optimizing the efficacy and safety of
antifungal therapy because of the large variability in drug pharmacokinetics. Rapid …
antifungal therapy because of the large variability in drug pharmacokinetics. Rapid …