The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Cell-penetrating peptide-based delivery of macromolecular drugs: development, strategies, and progress

Z Sun, J Huang, Z Fishelson, C Wang, S Zhang - Biomedicines, 2023 - mdpi.com
Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …

Current therapeutic approaches and promising perspectives of using bioengineered peptides in fighting chemoresistance in triple-negative breast cancer

M Azari, F Bahreini, VN Uversky, N Rezaei - Biochemical Pharmacology, 2023 - Elsevier
Breast cancer is a collation of malignancies that manifest in the mammary glands at the early
stages. Among breast cancer subtypes, triple-negative breast cancer (TNBC) shows the …

Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer

RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Designed multifunctional peptides for intracellular targets

D Juretić - Antibiotics, 2022 - mdpi.com
Nature's way for bioactive peptides is to provide them with several related functions and the
ability to cooperate in performing their job. Natural cell-penetrating peptides (CPP), such as …

[HTML][HTML] Cellular uptake and trafficking of peptide-based drug delivery systems for miRNA

I Ruseska, A Zimmer - European Journal of Pharmaceutics and …, 2023 - Elsevier
Today, macromolecular compounds such as microRNAs (miRNAs) are becoming more and
more widespread as leading therapeutics. However, their application is limited mostly due to …

Peptide-based vectors: A biomolecular engineering strategy for gene delivery

S Urandur, MO Sullivan - Annual Review of Chemical and …, 2023 - annualreviews.org
From the first clinical trial by Dr. WF Anderson to the most recent US Food and Drug
Administration–approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis …

Cell penetrating peptides: Highlighting points in cancer therapy

AM Asrorov, H Wang, M Zhang, Y Wang… - Drug Development …, 2023 - Wiley Online Library
Abstract Cell‐penetrating peptides (CPPs), first identified in HIV a few decades ago,
deserved great attention in the last two decades; especially to support the penetration of …