Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Lipid metabolic reprogramming is involved in mediating tamoxifen (TAM) response in breast
cancer cells. Published microarray data indicated that ATP citrate lyase (ACLY) is …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by
reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the …

Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells
and facilitate cancer development and progression. However, recent evidence suggests the …

Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of
fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid …

Obesity is reaching global epidemic proportions as a result of factors such as high-calorie
diets and lack of physical exercise. Obesity is now considered to be a medical condition …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Obesity is a medical situation in which excess body fat has gathered because of imbalance
between energy intake and energy expenditure. In spite of the fact that the variety of studies …