Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …

The incidence of heart failure (HF) is generally preceded by cardiac hypertrophy (CH), which
is the enlargement of cardiac myocytes in response to stress. During CH, the metabolism of …

Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …

Mainstream transcriptome profiling of susceptibility versus resistance to age-related
diseases (ARDs) is focused on differentially expressed genes (DEGs) specific to gender …

CTG repeat expansion (CTG exp) is associated with aberrant alternate splicing that
contributes to cardiac dysfunction in myotonic dystrophy type 1 (DM1). Excision of this CTG …

Biotransformation by phase I and II metabolizing enzymes represents the major determinant
for the oral bioavailability of many drugs. To estimate the pharmacokinetics, data on protein …

ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …

Abstract Cytochrome P450 2 J2 (CYP2J2) is primarily expressed extrahepatically and is the
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …

Myocardial disease, the abnormalities of the cardiac muscle, is the leading cause of death in
humans. Eicosanoids represent a large spectrum of lipid mediators with critical roles in …

Objective Metabolites derived from N− 3 and N− 6 polyunsaturated fatty acids (PUFAs) have
both beneficial and detrimental effects on the heart. However, contribution of these lipid …